NRXN2 [The Human Chemical-Genetic Interaction Map Project]

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======= NRXN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRXN2
  * **<color #00a2e8>Official Name</color>**: neurexin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9379|9379]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/"P58401|Q9P2S2"|"P58401|Q9P2S2"]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRXN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRXN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600566|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin G 1|
|Laminin G 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gephyrin clustering involved in postsynaptic density assembly|
|neuroligin clustering involved in postsynaptic membrane assembly|
|neuroligin family protein binding|
|postsynaptic density protein 95 clustering|
|postsynaptic density assembly|
|vocal learning|
|imitative learning|
|observational learning|
|postsynaptic specialization assembly|
|learned vocalization behavior or vocal learning|
|postsynaptic membrane assembly|
|auditory behavior|
|excitatory synapse assembly|
|mechanosensory behavior|
|neuron cell-cell adhesion|
|postsynaptic density organization|
|vocalization behavior|
|postsynaptic specialization organization|
|postsynapse assembly|
|response to auditory stimulus|
|postsynaptic membrane organization|
|membrane assembly|
|calcium channel regulator activity|
|membrane biogenesis|
|receptor clustering|
|social behavior|
|intraspecies interaction between organisms|
|cell adhesion molecule binding|
|protein localization to synapse|
|multi-organism behavior|
|localization within membrane|
|postsynapse organization|
|synapse assembly|
|presynapse|
|signal release from synapse|
|neurotransmitter secretion|
|transmembrane signaling receptor activity|
|adult behavior|
|learning|
|signal release|
|neurotransmitter transport|
|response to mechanical stimulus|
|learning or memory|
|synapse organization|
|cognition|
|regulation of neurotransmitter levels|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|synaptic signaling|
|protein localization to membrane|
|cell-cell adhesion|
|behavior|
|organelle assembly|
|membrane organization|
|cell adhesion|
|biological adhesion|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|response to abiotic stimulus|
|nervous system process|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of localization in cell|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12578
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.63 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRXN2 Expression in NALM6 Cells: 0.63'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>