NSG1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= NSG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSG1
  * **<color #00a2e8>Official Name</color>**: neuronal vesicle trafficking associated 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27065|27065]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42857|P42857]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NSG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NSG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607645|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061). {ECO:0000250|UniProtKB:P02683, ECO:0000250|UniProtKB:Q62092, ECO:0000269|PubMed:20599942, ECO:0000269|PubMed:20878061}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Calcyon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurotransmitter receptor cycle|
|postsynaptic neurotransmitter receptor cycle|
|postsynaptic endosome|
|spontaneous synaptic transmission|
|clathrin light chain binding|
|neurotransmitter receptor transport, endosome to plasma membrane|
|neurotransmitter receptor transport, endosome to postsynaptic membrane|
|endosome to plasma membrane protein transport|
|somatodendritic compartment|
|receptor recycling|
|multivesicular body membrane|
|positive regulation of receptor recycling|
|neurotransmitter receptor transport to plasma membrane|
|neurotransmitter receptor transport to postsynaptic membrane|
|establishment of protein localization to postsynaptic membrane|
|amyloid precursor protein metabolic process|
|clathrin coat assembly|
|regulation of receptor recycling|
|retrograde transport, endosome to plasma membrane|
|neurotransmitter receptor transport|
|protein localization to postsynaptic membrane|
|dopamine receptor signaling pathway|
|receptor localization to synapse|
|regulation of long-term synaptic potentiation|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|establishment of protein localization to plasma membrane|
|lateral plasma membrane|
|protein localization to synapse|
|recycling endosome membrane|
|cellular response to dopamine|
|response to dopamine|
|trans-Golgi network membrane|
|signal transduction involved in cellular response to ammonium ion|
|Golgi cisterna membrane|
|vesicle-mediated transport to the plasma membrane|
|lysosomal lumen|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|receptor metabolic process|
|response to monoamine|
|response to catecholamine|
|late endosome|
|cellular response to ammonium ion|
|vesicle-mediated transport in synapse|
|cytoplasmic vesicle membrane|
|early endosome membrane|
|protein localization to plasma membrane|
|response to ammonium ion|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|endosomal transport|
|protein localization to cell periphery|
|protein-containing complex localization|
|establishment of protein localization to membrane|
|endosome|
|signaling receptor binding|
|glutamatergic synapse|
|cellular response to drug|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|protein localization to membrane|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|cellular protein-containing complex assembly|
|response to organic cyclic compound|
|apoptotic process|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|response to organonitrogen compound|
|endoplasmic reticulum|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell death|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13685
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: N/A 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NSG1 Expression in NALM6 Cells: N/A'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>