NSMCE1 [The Human Chemical-Genetic Interaction Map Project]

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======= NSMCE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSMCE1
  * **<color #00a2e8>Official Name</color>**: NSE1 homolog, SMC5-SMC6 complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=197370|197370]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WV22|Q8WV22]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NSMCE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NSMCE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617263|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NSMCE3. Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888, ECO:0000269|PubMed:20864041}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-RING-like|
|SMC Nse1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Smc5-Smc6 complex|
|chromosome, telomeric region|
|postreplication repair|
|double-strand break repair via homologous recombination|
|positive regulation of response to DNA damage stimulus|
|recombinational repair|
|protein dimerization activity|
|double-strand break repair|
|regulation of response to DNA damage stimulus|
|DNA recombination|
|ubiquitin-protein transferase activity|
|DNA repair|
|intracellular membrane-bounded organelle|
|protein ubiquitination|
|regulation of cellular response to stress|
|DNA metabolic process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|protein modification by small protein conjugation or removal|
|regulation of response to stress|
|intracellular signal transduction|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-3.03|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.96|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.87|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.61|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.55|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.51|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.35|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.32|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.27|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.26|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.23|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.08|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.07|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.05|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.05|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-2.04|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.03|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2.03|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.02|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.98|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.91|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.91|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.88|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.82|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.82|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.79|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.79|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.79|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.77|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.76|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.75|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.73|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.73|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.71|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.71|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.7|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.87|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.683|
|[[:human genes:p:pmm2|PMM2]]|0.545|
|[[:human genes:g:gemin8|GEMIN8]]|0.539|
|[[:human genes:g:gemin5|GEMIN5]]|0.529|
|[[:human genes:n:nars|NARS]]|0.527|
|[[:human genes:n:nsmce2|NSMCE2]]|0.522|
|[[:human genes:t:tbca|TBCA]]|0.521|
|[[:human genes:m:mars|MARS]]|0.515|
|[[:human genes:d:ddx20|DDX20]]|0.513|
|[[:human genes:t:trmt5|TRMT5]]|0.508|
|[[:human genes:g:gfpt1|GFPT1]]|0.507|
|[[:human genes:g:gmppb|GMPPB]]|0.501|
|[[:human genes:o:osgep|OSGEP]]|0.5|
|[[:human genes:s:srp14|SRP14]]|0.499|
|[[:human genes:u:uap1|UAP1]]|0.499|
|[[:human genes:r:rabggtb|RABGGTB]]|0.496|
|[[:human genes:e:eno1|ENO1]]|0.496|
|[[:human genes:d:dpagt1|DPAGT1]]|0.492|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.486|
|[[:human genes:n:nae1|NAE1]]|0.485|
|[[:human genes:t:tbcd|TBCD]]|0.484|
|[[:human genes:r:rad1|RAD1]]|0.484|
|[[:human genes:r:rnmt|RNMT]]|0.483|
|[[:human genes:a:alg1|ALG1]]|0.482|
|[[:human genes:r:rpe|RPE]]|0.48|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.479|
|[[:human genes:r:rtcb|RTCB]]|0.478|
|[[:human genes:h:haus8|HAUS8]]|0.472|
|[[:human genes:v:vrk1|VRK1]]|0.472|
|[[:human genes:t:triap1|TRIAP1]]|0.471|
|[[:human genes:f:fnta|FNTA]]|0.465|
|[[:human genes:p:pam16|PAM16]]|0.465|
|[[:human genes:e:exoc3|EXOC3]]|0.463|
|[[:human genes:s:srp68|SRP68]]|0.461|
|[[:human genes:s:smc6|SMC6]]|0.458|
|[[:human genes:s:srp72|SRP72]]|0.457|
|[[:human genes:g:ggps1|GGPS1]]|0.454|
|[[:human genes:r:rpp21|RPP21]]|0.452|
|[[:human genes:t:thg1l|THG1L]]|0.451|
|[[:human genes:r:rbm14|RBM14]]|0.448|
|[[:human genes:h:hspd1|HSPD1]]|0.448|
|[[:human genes:a:alg5|ALG5]]|0.446|
|[[:human genes:g:gtf3a|GTF3A]]|0.445|
|[[:human genes:d:dhps|DHPS]]|0.442|
|[[:human genes:t:tsen54|TSEN54]]|0.442|
|[[:human genes:a:alg14|ALG14]]|0.442|
|[[:human genes:u:ube2k|UBE2K]]|0.442|
|[[:human genes:g:gnb1l|GNB1L]]|0.441|
|[[:human genes:t:tti2|TTI2]]|0.441|
|[[:human genes:p:pmpcb|PMPCB]]|0.44|
|[[:human genes:a:alg2|ALG2]]|0.438|
|[[:human genes:e:eprs|EPRS]]|0.435|
|[[:human genes:a:adsl|ADSL]]|0.432|
|[[:human genes:t:txnl4b|TXNL4B]]|0.432|
|[[:human genes:p:polr3h|POLR3H]]|0.43|
|[[:human genes:c:c14orf80|C14orf80]]|0.429|
|[[:human genes:d:dad1|DAD1]]|0.429|
|[[:human genes:a:atxn10|ATXN10]]|0.429|
|[[:human genes:d:ddost|DDOST]]|0.427|
|[[:human genes:t:tti1|TTI1]]|0.426|
|[[:human genes:s:smc5|SMC5]]|0.424|
|[[:human genes:e:exoc4|EXOC4]]|0.423|
|[[:human genes:z:znf259|ZNF259]]|0.423|
|[[:human genes:p:ppp4c|PPP4C]]|0.422|
|[[:human genes:a:aars|AARS]]|0.422|
|[[:human genes:t:telo2|TELO2]]|0.421|
|[[:human genes:e:eny2|ENY2]]|0.42|
|[[:human genes:t:tpi1|TPI1]]|0.42|
|[[:human genes:u:uxt|UXT]]|0.419|
|[[:human genes:p:pelo|PELO]]|0.418|
|[[:human genes:z:zrsr2|ZRSR2]]|0.417|
|[[:human genes:v:vezt|VEZT]]|0.416|
|[[:human genes:t:timm22|TIMM22]]|0.415|
|[[:human genes:t:taf1a|TAF1A]]|0.415|
|[[:human genes:g:gemin6|GEMIN6]]|0.415|
|[[:human genes:w:wdr1|WDR1]]|0.414|
|[[:human genes:b:bub3|BUB3]]|0.414|
|[[:human genes:t:trappc3|TRAPPC3]]|0.413|
|[[:human genes:u:uhrf1|UHRF1]]|0.413|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.413|
|[[:human genes:e:eif4e|EIF4E]]|0.411|
|[[:human genes:s:sugt1|SUGT1]]|0.411|
|[[:human genes:p:pgk1|PGK1]]|0.41|
|[[:human genes:t:thoc3|THOC3]]|0.409|
|[[:human genes:t:ten1|TEN1]]|0.408|
|[[:human genes:c:cep350|CEP350]]|0.407|
|[[:human genes:c:csnk2b|CSNK2B]]|0.407|
|[[:human genes:d:dhdds|DHDDS]]|0.405|
|[[:human genes:t:tamm41|TAMM41]]|0.405|
|[[:human genes:c:chchd4|CHCHD4]]|0.402|
|[[:human genes:k:kars|KARS]]|0.402|
|[[:human genes:t:tkt|TKT]]|0.401|
|[[:human genes:r:rptor|RPTOR]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 298/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|14/28|
|bone|18/26|
|breast|13/33|
|central nervous system|28/56|
|cervix|2/4|
|colorectal|6/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|6/21|
|liver|6/20|
|lung|22/75|
|lymphocyte|3/16|
|ovary|11/26|
|pancreas|13/24|
|peripheral nervous system|5/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|3/9|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|19/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 820
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NSMCE1 Expression in NALM6 Cells: 5.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>