NTF3 [The Human Chemical-Genetic Interaction Map Project]

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======= NTF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NTF3
  * **<color #00a2e8>Official Name</color>**: neurotrophin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4908|4908]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20783|P20783]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NTF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NTF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162660|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to promote the survival of visceral and proprioceptive sensory neurons.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurotrophin receptor binding|
|positive regulation of neurotrophin TRK receptor signaling pathway|
|nerve growth factor signaling pathway|
|regulation of neurotrophin TRK receptor signaling pathway|
|induction of positive chemotaxis|
|positive regulation of actin cytoskeleton reorganization|
|positive regulation of receptor internalization|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|neurotrophin signaling pathway|
|activation of protein kinase B activity|
|chemoattractant activity|
|regulation of actin cytoskeleton reorganization|
|positive regulation of phospholipase C activity|
|regulation of phospholipase C activity|
|positive chemotaxis|
|cellular response to nerve growth factor stimulus|
|negative regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of receptor-mediated endocytosis|
|response to nerve growth factor|
|regulation of receptor internalization|
|positive regulation of phospholipase activity|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|peripheral nervous system development|
|nerve development|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|regulation of lipase activity|
|activation of GTPase activity|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|positive regulation of peptidyl-serine phosphorylation|
|memory|
|regulation of phosphatidylinositol 3-kinase signaling|
|synaptic vesicle|
|positive regulation of chemotaxis|
|regulation of peptidyl-serine phosphorylation|
|negative regulation of neuron apoptotic process|
|activation of MAPK activity|
|growth factor activity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of endocytosis|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of chemotaxis|
|positive regulation of cytoskeleton organization|
|cytoplasmic vesicle|
|regulation of peptidyl-tyrosine phosphorylation|
|learning or memory|
|positive regulation of MAP kinase activity|
|regulation of cellular response to growth factor stimulus|
|axon|
|cognition|
|regulation of neuron death|
|activation of protein kinase activity|
|signaling receptor binding|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of actin filament-based process|
|negative regulation of protein phosphorylation|
|positive regulation of GTPase activity|
|dendrite|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|behavior|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|neuron projection development|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15001
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NTF3 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>