NTNG2 [The Human Chemical-Genetic Interaction Map Project]

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======= NTNG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NTNG2
  * **<color #00a2e8>Official Name</color>**: netrin G2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84628|84628]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CW9|Q96CW9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NTNG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NTNG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618689|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin EGF|
|Laminin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anchored component of presynaptic active zone membrane|
|postsynaptic specialization assembly|
|postsynaptic specialization organization|
|postsynapse assembly|
|synaptic membrane adhesion|
|motor neuron axon guidance|
|regulation of presynapse assembly|
|Flemming body|
|regulation of presynapse organization|
|anchored component of plasma membrane|
|intercellular bridge|
|Schaffer collateral - CA1 synapse|
|postsynapse organization|
|synapse assembly|
|regulation of synapse assembly|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|neuron projection guidance|
|synapse organization|
|axon|
|glutamatergic synapse|
|axonogenesis|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell-cell adhesion|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|neuron projection development|
|cell morphogenesis|
|organelle assembly|
|molecular function|
|neuron development|
|cellular component morphogenesis|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.96|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.79|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.71|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.72|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.74|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.87|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10284
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NTNG2 Expression in NALM6 Cells: 2.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>