NTSR1 [The Human Chemical-Genetic Interaction Map Project]

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======= NTSR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NTSR1
  * **<color #00a2e8>Official Name</color>**: neurotensin receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4923|4923]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30989|P30989]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NTSR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NTSR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162651|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). {ECO:0000269|PubMed:21725197, ECO:0000269|PubMed:23140271, ECO:0000269|PubMed:8381365}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srv|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|G protein-coupled neurotensin receptor activity|
|positive regulation of gamma-aminobutyric acid secretion|
|D-aspartate import across plasma membrane|
|D-aspartate transport|
|symmetric synapse|
|regulation of gamma-aminobutyric acid secretion|
|positive regulation of arachidonic acid secretion|
|modulation of inhibitory postsynaptic potential|
|positive regulation of inhibitory postsynaptic potential|
|D-amino acid transport|
|L-glutamate import across plasma membrane|
|regulation of arachidonic acid secretion|
|L-glutamate import|
|positive regulation of glutamate secretion|
|positive regulation of inositol phosphate biosynthetic process|
|negative regulation of release of sequestered calcium ion into cytosol|
|detection of temperature stimulus involved in sensory perception|
|detection of temperature stimulus involved in sensory perception of pain|
|amino acid import across plasma membrane|
|regulation of inositol phosphate biosynthetic process|
|regulation of glutamate secretion|
|inositol phosphate catabolic process|
|positive regulation of sequestering of calcium ion|
|positive regulation of icosanoid secretion|
|positive regulation of amino acid transport|
|negative regulation of systemic arterial blood pressure|
|negative regulation of calcium ion transport into cytosol|
|positive regulation of fatty acid transport|
|L-glutamate transmembrane transport|
|regulation of icosanoid secretion|
|detection of temperature stimulus|
|sensory perception of temperature stimulus|
|amino acid import|
|regulation of respiratory gaseous exchange|
|C4-dicarboxylate transport|
|positive regulation of alcohol biosynthetic process|
|polyol catabolic process|
|regulation of fatty acid transport|
|neurotransmitter uptake|
|temperature homeostasis|
|regulation of amino acid transport|
|positive regulation of organic acid transport|
|positive regulation of amine transport|
|dendritic shaft|
|positive regulation of neurotransmitter transport|
|regulation of sensory perception of pain|
|negative regulation of calcium ion transmembrane transport|
|positive regulation of release of sequestered calcium ion into cytosol|
|regulation of sensory perception|
|regulation of membrane depolarization|
|negative regulation of blood pressure|
|L-alpha-amino acid transmembrane transport|
|acidic amino acid transport|
|terminal bouton|
|regulation of action potential|
|positive regulation of anion transport|
|cytoplasmic side of plasma membrane|
|positive regulation of calcium ion transport into cytosol|
|alcohol catabolic process|
|inositol phosphate metabolic process|
|regulation of organic acid transport|
|positive regulation of cellular carbohydrate metabolic process|
|L-amino acid transport|
|negative regulation of calcium ion transport|
|positive regulation of lipid transport|
|positive regulation of nervous system process|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|drug transmembrane transport|
|regulation of alcohol biosynthetic process|
|sensory perception of pain|
|organic hydroxy compound catabolic process|
|adult locomotory behavior|
|amino acid transmembrane transport|
|regulation of release of sequestered calcium ion into cytosol|
|positive regulation of carbohydrate metabolic process|
|dicarboxylic acid transport|
|positive regulation of lipid localization|
|negative regulation of cation transmembrane transport|
|regulation of amine transport|
|regulation of systemic arterial blood pressure|
|regulation of carbohydrate biosynthetic process|
|negative regulation of ion transmembrane transport|
|regulation of anion transport|
|import across plasma membrane|
|regulation of calcium ion transport into cytosol|
|positive regulation of ion transmembrane transporter activity|
|neuropeptide signaling pathway|
|protein N-terminus binding|
|regulation of lipid transport|
|polyol metabolic process|
|positive regulation of transporter activity|
|negative regulation of transmembrane transport|
|amino acid transport|
|detection of external stimulus|
|positive regulation of calcium ion transport|
|detection of abiotic stimulus|
|regulation of sequestering of calcium ion|
|organic acid transmembrane transport|
|organophosphate catabolic process|
|carboxylic acid transmembrane transport|
|perikaryon|
|regulation of nervous system process|
|regulation of lipid localization|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|positive regulation of cation transmembrane transport|
|regulation of neurotransmitter transport|
|adult behavior|
|learning|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|dendritic spine|
|drug transport|
|positive regulation of synaptic transmission|
|positive regulation of ion transmembrane transport|
|regulation of cation channel activity|
|response to temperature stimulus|
|neurotransmitter transport|
|regulation of blood pressure|
|locomotory behavior|
|positive regulation of transmembrane transport|
|regulation of carbohydrate metabolic process|
|membrane raft|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|anion transmembrane transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|carboxylic acid transport|
|organic acid transport|
|cognition|
|alcohol metabolic process|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|regulation of neurotransmitter levels|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|small molecule catabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|organic hydroxy compound metabolic process|
|organic anion transport|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|detection of stimulus involved in sensory perception|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|behavior|
|anion transport|
|regulation of system process|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|import into cell|
|detection of stimulus|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|response to lipid|
|protein homodimerization activity|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|ion transmembrane transport|
|sensory perception|
|Golgi apparatus|
|positive regulation of transport|
|negative regulation of cell death|
|endoplasmic reticulum|
|response to drug|
|identical protein binding|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|mitochondrion|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|regulation of apoptotic process|
|regulation of programmed cell death|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|regulation of transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8779
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NTSR1 Expression in NALM6 Cells: -5.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>