NUBPL [The Human Chemical-Genetic Interaction Map Project]

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======= NUBPL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUBPL
  * **<color #00a2e8>Official Name</color>**: nucleotide binding protein like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80224|80224]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TB37|Q8TB37]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUBPL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUBPL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613621|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic complex located in the inner mitochondrial membrane. Mutations in this gene cause mitochondrial complex I deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits. {ECO:0000269|PubMed:19752196}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CbiA|
|ParA|
|MipZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrion morphogenesis|
|iron-sulfur cluster assembly|
|metallo-sulfur cluster assembly|
|4 iron, 4 sulfur cluster binding|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex assembly|
|cofactor biosynthetic process|
|sulfur compound metabolic process|
|mitochondrial matrix|
|cofactor metabolic process|
|mitochondrion organization|
|cell part morphogenesis|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|mitochondrion|
|ATP binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.75|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.72|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.73|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.74|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.78|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.82|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.82|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.89|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.91|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.94|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.06|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.16|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.19|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.27|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.27|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.3|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.38|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.44|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.6|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.95|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.36|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufs2|NDUFS2]]|0.704|
|[[:human genes:a:acad9|ACAD9]]|0.688|
|[[:human genes:n:ndufb9|NDUFB9]]|0.667|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.663|
|[[:human genes:g:grsf1|GRSF1]]|0.662|
|[[:human genes:n:ndufb11|NDUFB11]]|0.661|
|[[:human genes:m:mto1|MTO1]]|0.651|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.646|
|[[:human genes:n:ndufa1|NDUFA1]]|0.641|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.63|
|[[:human genes:n:ndufa11|NDUFA11]]|0.627|
|[[:human genes:n:ndufc2|NDUFC2]]|0.622|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.621|
|[[:human genes:n:ndufa2|NDUFA2]]|0.62|
|[[:human genes:n:ndufb10|NDUFB10]]|0.613|
|[[:human genes:n:ndufa3|NDUFA3]]|0.598|
|[[:human genes:n:ndufv2|NDUFV2]]|0.597|
|[[:human genes:n:ndufs8|NDUFS8]]|0.593|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.591|
|[[:human genes:n:ndufb7|NDUFB7]]|0.586|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.567|
|[[:human genes:n:ndufc1|NDUFC1]]|0.567|
|[[:human genes:n:ndufb2|NDUFB2]]|0.566|
|[[:human genes:e:ecsit|ECSIT]]|0.561|
|[[:human genes:n:ndufa6|NDUFA6]]|0.557|
|[[:human genes:f:fastkd2|FASTKD2]]|0.557|
|[[:human genes:i:iba57|IBA57]]|0.555|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.553|
|[[:human genes:n:ndufa8|NDUFA8]]|0.55|
|[[:human genes:p:pet112|PET112]]|0.543|
|[[:human genes:p:pet117|PET117]]|0.542|
|[[:human genes:n:ndufv1|NDUFV1]]|0.542|
|[[:human genes:p:polg2|POLG2]]|0.541|
|[[:human genes:f:foxred1|FOXRED1]]|0.536|
|[[:human genes:n:ndufa9|NDUFA9]]|0.531|
|[[:human genes:m:mtif2|MTIF2]]|0.529|
|[[:human genes:n:ndufb4|NDUFB4]]|0.528|
|[[:human genes:n:ndufb6|NDUFB6]]|0.526|
|[[:human genes:n:ndufs5|NDUFS5]]|0.526|
|[[:human genes:s:ssbp1|SSBP1]]|0.518|
|[[:human genes:n:nsun4|NSUN4]]|0.518|
|[[:human genes:g:glrx5|GLRX5]]|0.517|
|[[:human genes:n:ndufa10|NDUFA10]]|0.516|
|[[:human genes:m:mettl17|METTL17]]|0.514|
|[[:human genes:p:pde12|PDE12]]|0.513|
|[[:human genes:n:ndufa13|NDUFA13]]|0.513|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.511|
|[[:human genes:t:tfb1m|TFB1M]]|0.51|
|[[:human genes:s:slc25a51|SLC25A51]]|0.51|
|[[:human genes:f:ftsj2|FTSJ2]]|0.509|
|[[:human genes:n:ndufb5|NDUFB5]]|0.508|
|[[:human genes:m:malsu1|MALSU1]]|0.506|
|[[:human genes:n:nfu1|NFU1]]|0.505|
|[[:human genes:n:ndufa5|NDUFA5]]|0.503|
|[[:human genes:s:sfxn4|SFXN4]]|0.503|
|[[:human genes:p:polg|POLG]]|0.498|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.498|
|[[:human genes:c:coq7|COQ7]]|0.498|
|[[:human genes:m:mterfd1|MTERFD1]]|0.495|
|[[:human genes:c:cars2|CARS2]]|0.494|
|[[:human genes:m:mcat|MCAT]]|0.485|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.484|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.484|
|[[:human genes:n:ndufs3|NDUFS3]]|0.484|
|[[:human genes:m:mtg1|MTG1]]|0.483|
|[[:human genes:c:c1qbp|C1QBP]]|0.482|
|[[:human genes:r:rmnd1|RMND1]]|0.48|
|[[:human genes:n:ndufs7|NDUFS7]]|0.48|
|[[:human genes:c:c12orf65|C12orf65]]|0.48|
|[[:human genes:c:chchd1|CHCHD1]]|0.479|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.477|
|[[:human genes:n:nars2|NARS2]]|0.476|
|[[:human genes:m:mrpl45|MRPL45]]|0.476|
|[[:human genes:l:lars2|LARS2]]|0.474|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.474|
|[[:human genes:q:qrsl1|QRSL1]]|0.472|
|[[:human genes:g:gfm2|GFM2]]|0.472|
|[[:human genes:m:mrps21|MRPS21]]|0.472|
|[[:human genes:n:ndufs1|NDUFS1]]|0.471|
|[[:human genes:c:c17orf89|C17orf89]]|0.469|
|[[:human genes:c:clpp|CLPP]]|0.466|
|[[:human genes:r:rpusd3|RPUSD3]]|0.465|
|[[:human genes:n:ndufb8|NDUFB8]]|0.465|
|[[:human genes:m:mipep|MIPEP]]|0.459|
|[[:human genes:c:coq2|COQ2]]|0.458|
|[[:human genes:p:ptcd3|PTCD3]]|0.455|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.455|
|[[:human genes:s:slc25a3|SLC25A3]]|0.455|
|[[:human genes:e:eral1|ERAL1]]|0.454|
|[[:human genes:t:tsfm|TSFM]]|0.452|
|[[:human genes:y:ybey|YBEY]]|0.446|
|[[:human genes:c:c10orf2|C10orf2]]|0.446|
|[[:human genes:d:ddx28|DDX28]]|0.445|
|[[:human genes:m:mrpl43|MRPL43]]|0.444|
|[[:human genes:n:noa1|NOA1]]|0.442|
|[[:human genes:a:atp5sl|ATP5SL]]|0.438|
|[[:human genes:m:mrpl44|MRPL44]]|0.438|
|[[:human genes:p:prim1|PRIM1]]|0.438|
|[[:human genes:p:prepl|PREPL]]|0.438|
|[[:human genes:m:mrpl21|MRPL21]]|0.434|
|[[:human genes:r:rars2|RARS2]]|0.433|
|[[:human genes:w:wbscr16|WBSCR16]]|0.432|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.431|
|[[:human genes:t:tmem261|TMEM261]]|0.431|
|[[:human genes:c:cluh|CLUH]]|0.429|
|[[:human genes:m:mrpl13|MRPL13]]|0.429|
|[[:human genes:s:slc25a52|SLC25A52]]|0.429|
|[[:human genes:m:mdh2|MDH2]]|0.428|
|[[:human genes:g:gfm1|GFM1]]|0.427|
|[[:human genes:i:ict1|ICT1]]|0.426|
|[[:human genes:c:coa3|COA3]]|0.425|
|[[:human genes:w:wars2|WARS2]]|0.425|
|[[:human genes:s:sco2|SCO2]]|0.42|
|[[:human genes:r:rbfa|RBFA]]|0.418|
|[[:human genes:m:mrps18b|MRPS18B]]|0.415|
|[[:human genes:m:mrp63|MRP63]]|0.415|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.413|
|[[:human genes:a:aars2|AARS2]]|0.411|
|[[:human genes:m:mrps16|MRPS16]]|0.411|
|[[:human genes:t:tars2|TARS2]]|0.409|
|[[:human genes:p:pars2|PARS2]]|0.408|
|[[:human genes:m:mrps27|MRPS27]]|0.407|
|[[:human genes:c:cox11|COX11]]|0.406|
|[[:human genes:m:mrps12|MRPS12]]|0.406|
|[[:human genes:c:cox18|COX18]]|0.406|
|[[:human genes:m:mrpl3|MRPL3]]|0.406|
|[[:human genes:y:yars2|YARS2]]|0.405|
|[[:human genes:t:tomm20|TOMM20]]|0.404|
|[[:human genes:m:mrpl47|MRPL47]]|0.404|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.403|
|[[:human genes:s:selrc1|SELRC1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 885
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUBPL Expression in NALM6 Cells: 4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>