NUCKS1 [The Human Chemical-Genetic Interaction Map Project]

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======= NUCKS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUCKS1
  * **<color #00a2e8>Official Name</color>**: nuclear casein kinase and cyclin dependent kinase substrate 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64710|64710]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1E3|Q9H1E3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUCKS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUCKS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611912|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modulation by host of RNA binding by virus|
|modulation by host of viral RNA-binding transcription factor activity|
|regulation of RNA binding transcription factor activity|
|release from viral latency|
|regulation of DNA strand elongation|
|latent virus replication|
|modulation by host of viral transcription|
|modulation by host of viral molecular function|
|gene conversion|
|positive regulation by host of viral genome replication|
|modulation by host of symbiont molecular function|
|cellular response to X-ray|
|modulation of molecular function in other organism|
|modulation of molecular function in other organism involved in symbiotic interaction|
|negative regulation by host of viral process|
|regulation of RNA binding|
|viral latency|
|negative regulation by host of viral transcription|
|modulation by host of viral genome replication|
|positive regulation by host of viral process|
|positive regulation by host of viral transcription|
|positive regulation of insulin receptor signaling pathway|
|positive regulation of cellular response to insulin stimulus|
|negative regulation of viral transcription|
|modulation by host of viral process|
|response to X-ray|
|replication fork processing|
|positive regulation of viral genome replication|
|DNA-dependent DNA replication maintenance of fidelity|
|positive regulation of viral transcription|
|interstrand cross-link repair|
|positive regulation of viral life cycle|
|regulation of viral transcription|
|regulation of insulin receptor signaling pathway|
|cellular response to ionizing radiation|
|modification by host of symbiont morphology or physiology|
|regulation of cellular response to insulin stimulus|
|interaction with symbiont|
|cellular glucose homeostasis|
|regulation of viral genome replication|
|double-strand break repair via homologous recombination|
|negative regulation of viral process|
|recombinational repair|
|double-stranded DNA binding|
|single-stranded DNA binding|
|positive regulation of viral process|
|regulation of DNA replication|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|chromatin|
|DNA-dependent DNA replication|
|regulation of viral life cycle|
|response to ionizing radiation|
|modification of morphology or physiology of other organism|
|cellular response to radiation|
|double-strand break repair|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of viral process|
|DNA replication|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|DNA recombination|
|nuclear chromatin|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|transcription factor binding|
|regulation of DNA metabolic process|
|regulation of binding|
|chromatin binding|
|response to radiation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of multi-organism process|
|DNA repair|
|chromatin organization|
|viral process|
|cellular chemical homeostasis|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|nucleolus|
|cellular homeostasis|
|chromosome organization|
|chemical homeostasis|
|negative regulation of molecular function|
|response to abiotic stimulus|
|positive regulation of transcription by RNA polymerase II|
|RNA binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.7|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.74|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.85|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.85|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.9|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16790
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUCKS1 Expression in NALM6 Cells: 8.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>