NUDT2 [The Human Chemical-Genetic Interaction Map Project]

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======= NUDT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUDT2
  * **<color #00a2e8>Official Name</color>**: nudix hydrolase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=318|318]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50583|P50583]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUDT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUDT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602852|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NUDIX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|bis(5-nucleosyl)-tetraphosphatase (symmetrical) activity|
|bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity|
|cellular response to oxidative stress|
|mitochondrial matrix|
|response to oxidative stress|
|GTP binding|
|apoptotic process|
|programmed cell death|
|cell death|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.39|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.26|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.97|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.88|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.77|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.76|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.39|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.74|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|5.35|
|[[:results:exp116|AICAR 240μM R03 exp116]]|8.48|
|[[:results:exp211|AICAR 240μM R05 exp211]]|8.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:adk|ADK]]|0.636|
|[[:human genes:a:ak2|AK2]]|0.539|
|[[:human genes:a:adss|ADSS]]|0.518|
|[[:human genes:m:mtr|MTR]]|0.516|
|[[:human genes:p:prune|PRUNE]]|0.486|
|[[:human genes:m:mmachc|MMACHC]]|0.43|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4378
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUDT2 Expression in NALM6 Cells: 2.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>