NUDT5 [The Human Chemical-Genetic Interaction Map Project]

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======= NUDT5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUDT5
  * **<color #00a2e8>Official Name</color>**: nudix hydrolase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11164|11164]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKK9|Q9UKK9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUDT5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUDT5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609230|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5- phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy- consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q9JKX6, ECO:0000269|PubMed:10567213, ECO:0000269|PubMed:10722730, ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:19699693, ECO:0000269|PubMed:21389046, ECO:0000269|PubMed:27257257}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NUDIX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ADP-sugar diphosphatase activity|
|8-oxo-dGDP phosphatase activity|
|D-ribose catabolic process|
|D-ribose metabolic process|
|ATP generation from poly-ADP-D-ribose|
|pentose catabolic process|
|ribonucleoside diphosphate catabolic process|
|ADP-ribose diphosphatase activity|
|nucleoside diphosphate catabolic process|
|m7G(5)pppN diphosphatase activity|
|nucleotidyltransferase activity|
|pentose metabolic process|
|snoRNA binding|
|nucleobase-containing small molecule catabolic process|
|monosaccharide catabolic process|
|ribonucleoside diphosphate metabolic process|
|nucleoside phosphate catabolic process|
|nucleoside diphosphate metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|carbohydrate catabolic process|
|organophosphate catabolic process|
|chromatin remodeling|
|monosaccharide metabolic process|
|ATP metabolic process|
|magnesium ion binding|
|ribose phosphate metabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|organic cyclic compound catabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|chromatin organization|
|protein homodimerization activity|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.91|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.7|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-2.54|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.5|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.49|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2.41|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.41|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.3|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.3|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.18|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.14|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.12|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-2.12|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.08|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.08|
|[[:results:exp16|DABN 2μM R00 exp16]]|-2.08|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.06|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.95|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.94|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.94|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.91|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.88|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.86|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.84|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.8|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.78|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-1.76|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.75|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.74|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.74|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.73|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.72|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.7|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.7|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.72|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.77|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.05|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.48|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.58|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.58|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.78|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.85|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.93|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.36|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|8.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9226
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUDT5 Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>