NUP153 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP153 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP153
  * **<color #00a2e8>Official Name</color>**: nucleoporin 153
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9972|9972]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49790|P49790]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP153&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP153|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603948|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat- containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nup153|
|zf-RanBP|
|Nup retrotrp bd|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of nucleobase-containing compound transport|
|negative regulation of RNA export from nucleus|
|multi-organism nuclear import|
|viral penetration into host nucleus|
|multi-organism cellular localization|
|multi-organism intracellular transport|
|nuclear pore central transport channel|
|nuclear pore complex assembly|
|nuclear pore nuclear basket|
|nuclear inclusion body|
|nuclear periphery|
|regulation of RNA export from nucleus|
|protein membrane anchor|
|nuclear pore organization|
|regulation of nucleobase-containing compound transport|
|negative regulation of nucleocytoplasmic transport|
|pore complex assembly|
|nuclear localization sequence binding|
|structural constituent of nuclear pore|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|intracellular transport of virus|
|host cell|
|transport of virus|
|negative regulation of intracellular transport|
|protein sumoylation|
|multi-organism transport|
|multi-organism localization|
|nuclear pore|
|regulation of cellular response to heat|
|regulation of glycolytic process|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|viral entry into host cell|
|protein import into nucleus|
|entry into host|
|entry into host cell|
|regulation of nucleocytoplasmic transport|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|viral transcription|
|import into nucleus|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|nucleus organization|
|protein import|
|protein export from nucleus|
|mRNA transport|
|interaction with host|
|regulation of generation of precursor metabolites and energy|
|nuclear export|
|protein localization to nucleus|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|peptidyl-lysine modification|
|regulation of intracellular transport|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|negative regulation of transport|
|viral process|
|regulation of cellular response to stress|
|protein localization to organelle|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|nucleolus|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|identical protein binding|
|DNA binding|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.05|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.99|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.87|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.71|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.7|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.7|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.74|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.74|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.75|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.76|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.81|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.81|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.86|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.87|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.98|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.03|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.09|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.2|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.564|
|[[:human genes:p:polr2j3|POLR2J3]]|0.516|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.51|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.508|
|[[:human genes:t:tceb3c|TCEB3C]]|0.5|
|[[:human genes:s:slc4a1|SLC4A1]]|0.497|
|[[:human genes:d:dtl|DTL]]|0.496|
|[[:human genes:c:chaf1a|CHAF1A]]|0.493|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.491|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.479|
|[[:human genes:p:psmb4|PSMB4]]|0.478|
|[[:human genes:n:npipb5|NPIPB5]]|0.476|
|[[:human genes:t:timeless|TIMELESS]]|0.472|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.47|
|[[:human genes:z:znf830|ZNF830]]|0.467|
|[[:human genes:c:chd4|CHD4]]|0.467|
|[[:human genes:t:ticrr|TICRR]]|0.466|
|[[:human genes:c:cdca3|CDCA3]]|0.461|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.457|
|[[:human genes:s:sec13|SEC13]]|0.456|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.454|
|[[:human genes:a:aqr|AQR]]|0.446|
|[[:human genes:c:cbwd3|CBWD3]]|0.446|
|[[:human genes:s:slc6a17|SLC6A17]]|0.444|
|[[:human genes:s:ssh2|SSH2]]|0.441|
|[[:human genes:a:akirin2|AKIRIN2]]|0.441|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.439|
|[[:human genes:v:vasn|VASN]]|0.437|
|[[:human genes:i:ik|IK]]|0.436|
|[[:human genes:s:supt6h|SUPT6H]]|0.436|
|[[:human genes:n:nupl1|NUPL1]]|0.435|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.435|
|[[:human genes:s:smg1|SMG1]]|0.435|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.434|
|[[:human genes:s:supt5h|SUPT5H]]|0.432|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.431|
|[[:human genes:n:nup160|NUP160]]|0.43|
|[[:human genes:c:cbwd6|CBWD6]]|0.427|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.427|
|[[:human genes:a:ahctf1|AHCTF1]]|0.427|
|[[:human genes:g:gid4|GID4]]|0.426|
|[[:human genes:c:cdh24|CDH24]]|0.425|
|[[:human genes:d:ddtl|DDTL]]|0.424|
|[[:human genes:s:snx15|SNX15]]|0.424|
|[[:human genes:p:pole|POLE]]|0.423|
|[[:human genes:p:psmc2|PSMC2]]|0.423|
|[[:human genes:s:syt9|SYT9]]|0.422|
|[[:human genes:c:copb1|COPB1]]|0.42|
|[[:human genes:p:pan2|PAN2]]|0.418|
|[[:human genes:c:cdc45|CDC45]]|0.418|
|[[:human genes:p:psma6|PSMA6]]|0.418|
|[[:human genes:p:psmb3|PSMB3]]|0.417|
|[[:human genes:p:psmb2|PSMB2]]|0.417|
|[[:human genes:s:srgap2c|SRGAP2C]]|0.417|
|[[:human genes:r:rangap1|RANGAP1]]|0.417|
|[[:human genes:r:ranbp2|RANBP2]]|0.416|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.416|
|[[:human genes:t:tyms|TYMS]]|0.415|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.415|
|[[:human genes:z:zfand5|ZFAND5]]|0.415|
|[[:human genes:r:rpl30|RPL30]]|0.415|
|[[:human genes:c:cope|COPE]]|0.413|
|[[:human genes:l:lipe|LIPE]]|0.413|
|[[:human genes:c:cln6|CLN6]]|0.413|
|[[:human genes:n:nipbl|NIPBL]]|0.413|
|[[:human genes:n:nup214|NUP214]]|0.412|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.412|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.412|
|[[:human genes:p:psmd3|PSMD3]]|0.412|
|[[:human genes:z:znf655|ZNF655]]|0.412|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.412|
|[[:human genes:c:cbwd5|CBWD5]]|0.412|
|[[:human genes:p:psmd7|PSMD7]]|0.411|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.411|
|[[:human genes:n:napa|NAPA]]|0.41|
|[[:human genes:n:nup62|NUP62]]|0.41|
|[[:human genes:n:nsf|NSF]]|0.409|
|[[:human genes:r:rps12|RPS12]]|0.409|
|[[:human genes:r:rpl35|RPL35]]|0.409|
|[[:human genes:m:mt1e|MT1E]]|0.408|
|[[:human genes:x:xylt2|XYLT2]]|0.408|
|[[:human genes:s:scaf1|SCAF1]]|0.407|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.407|
|[[:human genes:l:loc643669|LOC643669]]|0.407|
|[[:human genes:s:snrpa1|SNRPA1]]|0.405|
|[[:human genes:t:tfip11|TFIP11]]|0.405|
|[[:human genes:m:med17|MED17]]|0.404|
|[[:human genes:w:wdr43|WDR43]]|0.403|
|[[:human genes:k:krt78|KRT78]]|0.403|
|[[:human genes:h:hivep3|HIVEP3]]|0.403|
|[[:human genes:d:ddt|DDT]]|0.402|
|[[:human genes:c:clasp1|CLASP1]]|0.402|
|[[:human genes:n:nup85|NUP85]]|0.401|
|[[:human genes:p:pola2|POLA2]]|0.401|
|[[:human genes:g:gar1|GAR1]]|0.4|
|[[:human genes:d:ddx47|DDX47]]|0.4|
|[[:human genes:a:aamp|AAMP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 59/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|1/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|2/20|
|lung|11/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|3/24|
|peripheral nervous system|3/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 857
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP153 Expression in NALM6 Cells: 7.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>