NUP188 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP188 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP188
  * **<color #00a2e8>Official Name</color>**: nucleoporin 188
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23511|23511]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5SRE5|Q5SRE5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP188&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP188|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615587|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a component of the nuclear pore complex (NPC).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nup188|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pore inner ring|
|structural constituent of nuclear pore|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism transport|
|multi-organism localization|
|regulation of cellular response to heat|
|regulation of glycolytic process|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|protein import into nucleus|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|viral transcription|
|import into nucleus|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|protein import|
|protein export from nucleus|
|mRNA transport|
|regulation of generation of precursor metabolites and energy|
|nuclear export|
|protein localization to nucleus|
|nuclear envelope|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|peptidyl-lysine modification|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|viral process|
|regulation of cellular response to stress|
|protein localization to organelle|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.89|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.7|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.73|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.74|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.91|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.01|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.41|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:smg7|SMG7]]|0.524|
|[[:human genes:s:ssh2|SSH2]]|0.492|
|[[:human genes:r:ranbp1|RANBP1]]|0.476|
|[[:human genes:n:nup54|NUP54]]|0.457|
|[[:human genes:a:aaas|AAAS]]|0.45|
|[[:human genes:n:ndc1|NDC1]]|0.441|
|[[:human genes:o:otub1|OTUB1]]|0.433|
|[[:human genes:a:atp13a1|ATP13A1]]|0.43|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.425|
|[[:human genes:m:mdm2|MDM2]]|0.423|
|[[:human genes:z:zfand5|ZFAND5]]|0.414|
|[[:human genes:p:prpf8|PRPF8]]|0.414|
|[[:human genes:o:orc1|ORC1]]|0.408|
|[[:human genes:c:cnot1|CNOT1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 975
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP188 Expression in NALM6 Cells: 8.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>