NUP205 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP205 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP205
  * **<color #00a2e8>Official Name</color>**: nucleoporin 205
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23165|23165]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92621|Q92621]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP205&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP205|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614352|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. Mutations in this gene are associated with steroid-resistant nephrotic syndrome. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC. {ECO:0000269|PubMed:15229283}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3414|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pore inner ring|
|nuclear pore complex assembly|
|nuclear pore organization|
|nuclear periphery|
|pore complex assembly|
|structural constituent of nuclear pore|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism localization|
|multi-organism transport|
|nuclear pore|
|regulation of cellular response to heat|
|regulation of glycolytic process|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|viral transcription|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|nucleus organization|
|protein export from nucleus|
|mRNA transport|
|regulation of generation of precursor metabolites and energy|
|nuclear export|
|nuclear envelope|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|peptidyl-lysine modification|
|regulation of small molecule metabolic process|
|viral process|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|intracellular protein transport|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.32|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.93|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.9|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.75|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.71|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.73|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.76|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.77|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.8|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.86|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.89|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.91|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.94|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.08|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|2.08|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.14|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.19|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.2|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.84|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.91|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|3.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:supt6h|SUPT6H]]|0.525|
|[[:human genes:p:pan3|PAN3]]|0.488|
|[[:human genes:o:orc1|ORC1]]|0.483|
|[[:human genes:v:vasn|VASN]]|0.482|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.476|
|[[:human genes:c:chd4|CHD4]]|0.474|
|[[:human genes:l:lrr1|LRR1]]|0.473|
|[[:human genes:t:tceb3c|TCEB3C]]|0.468|
|[[:human genes:p:psmc6|PSMC6]]|0.468|
|[[:human genes:n:nupl1|NUPL1]]|0.465|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.458|
|[[:human genes:p:pola1|POLA1]]|0.454|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.454|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.451|
|[[:human genes:l:lad1|LAD1]]|0.45|
|[[:human genes:c:c14orf93|C14orf93]]|0.449|
|[[:human genes:e:exosc5|EXOSC5]]|0.447|
|[[:human genes:p:pan2|PAN2]]|0.446|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.445|
|[[:human genes:r:rpsa|RPSA]]|0.445|
|[[:human genes:c:cbwd3|CBWD3]]|0.443|
|[[:human genes:d:ddtl|DDTL]]|0.443|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.442|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.442|
|[[:human genes:p:pcf11|PCF11]]|0.442|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.441|
|[[:human genes:u:upf1|UPF1]]|0.44|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.438|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.437|
|[[:human genes:p:paf1|PAF1]]|0.436|
|[[:human genes:c:clpx|CLPX]]|0.436|
|[[:human genes:n:nup160|NUP160]]|0.436|
|[[:human genes:n:nup155|NUP155]]|0.435|
|[[:human genes:s:supt5h|SUPT5H]]|0.434|
|[[:human genes:p:pigs|PIGS]]|0.432|
|[[:human genes:p:pole|POLE]]|0.431|
|[[:human genes:o:osbp|OSBP]]|0.43|
|[[:human genes:c:cdca3|CDCA3]]|0.43|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.43|
|[[:human genes:m:med14|MED14]]|0.429|
|[[:human genes:a:ankle2|ANKLE2]]|0.426|
|[[:human genes:a:arcn1|ARCN1]]|0.426|
|[[:human genes:s:slc6a17|SLC6A17]]|0.425|
|[[:human genes:p:psmb4|PSMB4]]|0.423|
|[[:human genes:m:mt1e|MT1E]]|0.423|
|[[:human genes:h:hap1|HAP1]]|0.422|
|[[:human genes:i:iscu|ISCU]]|0.422|
|[[:human genes:d:ddx21|DDX21]]|0.421|
|[[:human genes:d:disp2|DISP2]]|0.42|
|[[:human genes:r:rad51|RAD51]]|0.419|
|[[:human genes:c:ccna2|CCNA2]]|0.418|
|[[:human genes:k:krt78|KRT78]]|0.417|
|[[:human genes:r:rad21|RAD21]]|0.416|
|[[:human genes:c:copb1|COPB1]]|0.416|
|[[:human genes:s:sf3a1|SF3A1]]|0.416|
|[[:human genes:a:akirin2|AKIRIN2]]|0.415|
|[[:human genes:c:cbwd5|CBWD5]]|0.415|
|[[:human genes:c:cope|COPE]]|0.415|
|[[:human genes:m:mfsd12|MFSD12]]|0.415|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.414|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.413|
|[[:human genes:d:dhfr|DHFR]]|0.412|
|[[:human genes:z:zfand5|ZFAND5]]|0.412|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.411|
|[[:human genes:o:ogfr|OGFR]]|0.411|
|[[:human genes:m:mdm2|MDM2]]|0.41|
|[[:human genes:r:rpl35|RPL35]]|0.41|
|[[:human genes:n:nbpf10|NBPF10]]|0.409|
|[[:human genes:d:dtl|DTL]]|0.408|
|[[:human genes:r:rpl14|RPL14]]|0.407|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.405|
|[[:human genes:p:psma6|PSMA6]]|0.405|
|[[:human genes:g:golga6a|GOLGA6A]]|0.403|
|[[:human genes:n:nbpf16|NBPF16]]|0.403|
|[[:human genes:t:tfip11|TFIP11]]|0.402|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.401|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.4|
|[[:human genes:s:snrpa1|SNRPA1]]|0.4|
|[[:human genes:c:ckap5|CKAP5]]|0.4|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 613/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|26/28|
|bone|19/26|
|breast|25/33|
|central nervous system|48/56|
|cervix|0/4|
|colorectal|15/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|13/21|
|liver|18/20|
|lung|62/75|
|lymphocyte|15/16|
|ovary|23/26|
|pancreas|21/24|
|peripheral nervous system|15/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|22/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 981
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP205 Expression in NALM6 Cells: 8.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>