NUP35 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP35 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP35
  * **<color #00a2e8>Official Name</color>**: nucleoporin 35
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=129401|129401]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFH5|Q8NFH5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP35&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP35|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608140|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MPPN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pore central transport channel|
|nuclear lamina|
|nuclear pore nuclear basket|
|nuclear pore organization|
|NLS-bearing protein import into nucleus|
|structural constituent of nuclear pore|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism localization|
|multi-organism transport|
|regulation of glycolytic process|
|regulation of cellular response to heat|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|protein import into nucleus|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|phospholipid binding|
|single-stranded DNA binding|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|import into nucleus|
|viral transcription|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|regulation of gene silencing|
|viral gene expression|
|nucleus organization|
|protein import|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|regulation of generation of precursor metabolites and energy|
|protein localization to nucleus|
|nuclear envelope|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|peptidyl-lysine modification|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|viral process|
|protein localization to organelle|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|intracellular protein transport|
|cellular response to cytokine stimulus|
|response to cytokine|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.3|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.26|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.99|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.75|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.8|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ranbp1|RANBP1]]|0.438|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 27/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|3/26|
|breast|3/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3688
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP35 Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>