NUP54 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP54 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP54
  * **<color #00a2e8>Official Name</color>**: nucleoporin 54
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=53371|53371]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z3B4|Q7Z3B4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP54&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP54|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607607|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {ECO:0000250|UniProtKB:P70582}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to nuclear inner membrane|
|nuclear pore central transport channel|
|protein localization to nuclear envelope|
|protein heterotrimerization|
|nuclear pore organization|
|NLS-bearing protein import into nucleus|
|structural constituent of nuclear pore|
|protein heterotetramerization|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|protein trimerization|
|intracellular transport of virus|
|host cell|
|regulation of protein import into nucleus|
|transport of virus|
|regulation of protein import|
|protein sumoylation|
|multi-organism localization|
|multi-organism transport|
|regulation of cellular response to heat|
|regulation of glycolytic process|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|protein import into nucleus|
|regulation of nucleocytoplasmic transport|
|protein heterooligomerization|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|import into nucleus|
|viral transcription|
|regulation of protein localization to nucleus|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|nucleus organization|
|protein import|
|protein export from nucleus|
|protein tetramerization|
|mRNA transport|
|regulation of generation of precursor metabolites and energy|
|nuclear export|
|protein localization to nucleus|
|nuclear envelope|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|regulation of intracellular protein transport|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|peptidyl-lysine modification|
|protein homooligomerization|
|regulation of intracellular transport|
|protein targeting|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|protein localization to membrane|
|protein complex oligomerization|
|regulation of cellular protein localization|
|viral process|
|regulation of protein transport|
|protein localization to organelle|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|intracellular protein transport|
|regulation of protein localization|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.81|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.7|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vasn|VASN]]|0.536|
|[[:human genes:m:mylk3|MYLK3]]|0.511|
|[[:human genes:p:psmd1|PSMD1]]|0.502|
|[[:human genes:k:kctd17|KCTD17]]|0.483|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.482|
|[[:human genes:m:mt1e|MT1E]]|0.479|
|[[:human genes:l:lrr1|LRR1]]|0.476|
|[[:human genes:a:akirin2|AKIRIN2]]|0.476|
|[[:human genes:d:ddtl|DDTL]]|0.475|
|[[:human genes:p:psma6|PSMA6]]|0.47|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.469|
|[[:human genes:o:orc1|ORC1]]|0.468|
|[[:human genes:t:tceb3c|TCEB3C]]|0.464|
|[[:human genes:n:ndc1|NDC1]]|0.463|
|[[:human genes:r:rps12|RPS12]]|0.459|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.458|
|[[:human genes:n:nup188|NUP188]]|0.457|
|[[:human genes:c:c14orf93|C14orf93]]|0.456|
|[[:human genes:s:ssh2|SSH2]]|0.456|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.456|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.454|
|[[:human genes:n:nupl1|NUPL1]]|0.452|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.449|
|[[:human genes:c:ccna2|CCNA2]]|0.448|
|[[:human genes:o:orc6|ORC6]]|0.448|
|[[:human genes:a:atp13a1|ATP13A1]]|0.448|
|[[:human genes:e:elmod3|ELMOD3]]|0.447|
|[[:human genes:p:psmb2|PSMB2]]|0.446|
|[[:human genes:c:copg1|COPG1]]|0.442|
|[[:human genes:p:psmd3|PSMD3]]|0.442|
|[[:human genes:s:s1pr4|S1PR4]]|0.439|
|[[:human genes:i:igfn1|IGFN1]]|0.438|
|[[:human genes:o:ogfr|OGFR]]|0.436|
|[[:human genes:h:haus3|HAUS3]]|0.435|
|[[:human genes:e:exd1|EXD1]]|0.435|
|[[:human genes:a:ahctf1|AHCTF1]]|0.434|
|[[:human genes:p:psmd11|PSMD11]]|0.432|
|[[:human genes:s:snrpa1|SNRPA1]]|0.429|
|[[:human genes:p:psma7|PSMA7]]|0.428|
|[[:human genes:h:hmgcr|HMGCR]]|0.428|
|[[:human genes:r:rps2|RPS2]]|0.427|
|[[:human genes:e:eif4a3|EIF4A3]]|0.426|
|[[:human genes:a:aprt|APRT]]|0.425|
|[[:human genes:c:chd4|CHD4]]|0.424|
|[[:human genes:r:rrn3|RRN3]]|0.423|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.42|
|[[:human genes:a:aaas|AAAS]]|0.42|
|[[:human genes:s:scaf1|SCAF1]]|0.419|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.418|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.418|
|[[:human genes:c:cdc6|CDC6]]|0.418|
|[[:human genes:r:rps3|RPS3]]|0.416|
|[[:human genes:s:supt5h|SUPT5H]]|0.416|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.415|
|[[:human genes:r:rpsa|RPSA]]|0.414|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.413|
|[[:human genes:c:cdca3|CDCA3]]|0.412|
|[[:human genes:a:aqr|AQR]]|0.412|
|[[:human genes:p:psmd14|PSMD14]]|0.412|
|[[:human genes:p:psmc6|PSMC6]]|0.411|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.411|
|[[:human genes:p:psmd6|PSMD6]]|0.411|
|[[:human genes:s:supt6h|SUPT6H]]|0.411|
|[[:human genes:i:ints5|INTS5]]|0.41|
|[[:human genes:n:npipb8|NPIPB8]]|0.409|
|[[:human genes:p:polr2f|POLR2F]]|0.409|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.408|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.408|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.407|
|[[:human genes:z:zfand5|ZFAND5]]|0.407|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.407|
|[[:human genes:r:rbm39|RBM39]]|0.405|
|[[:human genes:k:kpnb1|KPNB1]]|0.405|
|[[:human genes:d:ddx56|DDX56]]|0.405|
|[[:human genes:p:psmd2|PSMD2]]|0.403|
|[[:human genes:p:psmb1|PSMB1]]|0.403|
|[[:human genes:s:sec13|SEC13]]|0.403|
|[[:human genes:r:rsph1|RSPH1]]|0.403|
|[[:human genes:a:atxn1|ATXN1]]|0.402|
|[[:human genes:t:tfip11|TFIP11]]|0.402|
|[[:human genes:m:myt1l|MYT1L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 308/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|10/28|
|blood|10/28|
|bone|13/26|
|breast|14/33|
|central nervous system|34/56|
|cervix|2/4|
|colorectal|5/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|6/21|
|liver|9/20|
|lung|26/75|
|lymphocyte|10/16|
|ovary|13/26|
|pancreas|6/24|
|peripheral nervous system|3/16|
|plasma cell|12/15|
|prostate|0/1|
|skin|11/24|
|soft tissue|1/9|
|thyroid|2/2|
|upper aerodigestive|6/22|
|urinary tract|10/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 685
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP54 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>