NUP62 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP62 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP62
  * **<color #00a2e8>Official Name</color>**: nucleoporin 62
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23636|23636]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P37198|P37198]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP62&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP62|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605815|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nsp1 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mitotic cytokinesis|
|regulation of mitotic cytokinetic process|
|positive regulation of mitotic cytokinetic process|
|PTB domain binding|
|regulation of cytokinetic process|
|annulate lamellae|
|regulation of mitotic cytokinesis|
|mitotic centrosome separation|
|positive regulation of centriole replication|
|positive regulation of protein localization to centrosome|
|nuclear pore central transport channel|
|centrosome separation|
|positive regulation of centrosome duplication|
|regulation of protein localization to centrosome|
|positive regulation of centrosome cycle|
|protein heterotrimerization|
|receptor signaling complex adaptor activity|
|regulation of centriole replication|
|centriole assembly|
|structural constituent of nuclear pore|
|Flemming body|
|thyroid hormone receptor binding|
|positive regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of ERBB signaling pathway|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|SH2 domain binding|
|tRNA transport|
|ncRNA export from nucleus|
|regulation of mitotic spindle organization|
|positive regulation of cytokinesis|
|Hsp90 protein binding|
|Hsp70 protein binding|
|kinesin binding|
|regulation of centrosome duplication|
|regulation of spindle organization|
|mitotic metaphase plate congression|
|negative regulation of epidermal growth factor receptor signaling pathway|
|negative regulation of ERBB signaling pathway|
|negative regulation of Ras protein signal transduction|
|positive regulation of mitotic nuclear division|
|protein trimerization|
|intracellular transport of virus|
|host cell|
|regulation of protein import into nucleus|
|metaphase plate congression|
|transport of virus|
|regulation of protein import|
|regulation of centrosome cycle|
|negative regulation of small GTPase mediated signal transduction|
|cell aging|
|positive regulation of nuclear division|
|protein sumoylation|
|multi-organism localization|
|multi-organism transport|
|nuclear pore|
|establishment of chromosome localization|
|chromosome localization|
|negative regulation of MAP kinase activity|
|positive regulation of organelle assembly|
|mitotic spindle|
|regulation of glycolytic process|
|regulation of cellular response to heat|
|ubiquitin binding|
|centrosome cycle|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of gene silencing by miRNA|
|positive regulation of cell division|
|regulation of carbohydrate catabolic process|
|regulation of cytokinesis|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|regulation of ERBB signaling pathway|
|microtubule organizing center organization|
|protein import into nucleus|
|phospholipid binding|
|regulation of nucleocytoplasmic transport|
|protein heterooligomerization|
|mitotic sister chromatid segregation|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|import into nucleus|
|viral transcription|
|regulation of purine nucleotide metabolic process|
|regulation of protein localization to nucleus|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|spindle pole|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|negative regulation of protein serine/threonine kinase activity|
|protein import|
|sister chromatid segregation|
|mitotic nuclear division|
|protein export from nucleus|
|positive regulation of mitotic cell cycle|
|ribonucleoprotein complex|
|mRNA transport|
|nuclear export|
|regulation of generation of precursor metabolites and energy|
|protein localization to nucleus|
|negative regulation of MAPK cascade|
|regulation of mitotic nuclear division|
|regulation of cell division|
|hormone-mediated signaling pathway|
|nuclear envelope|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|negative regulation of protein kinase activity|
|regulation of intracellular protein transport|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|nuclear membrane|
|nucleobase-containing compound transport|
|regulation of Ras protein signal transduction|
|negative regulation of kinase activity|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|chromosome segregation|
|negative regulation of transferase activity|
|aging|
|nuclear division|
|positive regulation of cell cycle process|
|organelle fission|
|peptidyl-lysine modification|
|positive regulation of cellular protein localization|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|regulation of intracellular transport|
|establishment of organelle localization|
|positive regulation of cell cycle|
|chromatin binding|
|negative regulation of protein phosphorylation|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|negative regulation of phosphorylation|
|microtubule cytoskeleton organization|
|centrosome|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|spermatogenesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|male gamete generation|
|organelle localization|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|microtubule-based process|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|gamete generation|
|viral process|
|regulation of protein transport|
|protein localization to organelle|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|organelle assembly|
|protein modification by small protein conjugation|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|multi-organism reproductive process|
|negative regulation of cell death|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|cell death|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.15|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.98|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.74|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.78|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.79|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.81|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps2|RPS2]]|0.451|
|[[:human genes:v:vasn|VASN]]|0.449|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.439|
|[[:human genes:s:sf3a1|SF3A1]]|0.435|
|[[:human genes:c:copb1|COPB1]]|0.432|
|[[:human genes:t:tceb3c|TCEB3C]]|0.43|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.429|
|[[:human genes:s:sec13|SEC13]]|0.425|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.424|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.423|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.422|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.422|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.421|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.421|
|[[:human genes:p:psma6|PSMA6]]|0.421|
|[[:human genes:p:psmb2|PSMB2]]|0.419|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.418|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.417|
|[[:human genes:p:psmc2|PSMC2]]|0.416|
|[[:human genes:n:nup153|NUP153]]|0.41|
|[[:human genes:m:med17|MED17]]|0.409|
|[[:human genes:n:npipb5|NPIPB5]]|0.409|
|[[:human genes:a:akirin2|AKIRIN2]]|0.408|
|[[:human genes:p:polr2j3|POLR2J3]]|0.408|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.407|
|[[:human genes:z:znf106|ZNF106]]|0.407|
|[[:human genes:c:c14orf93|C14orf93]]|0.405|
|[[:human genes:p:prim1|PRIM1]]|0.402|
|[[:human genes:p:pola2|POLA2]]|0.402|
|[[:human genes:c:cope|COPE]]|0.401|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.4|
|[[:human genes:s:sult2b1|SULT2B1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 266/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|8/28|
|bone|12/26|
|breast|13/33|
|central nervous system|17/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|5/16|
|kidney|1/21|
|liver|3/20|
|lung|28/75|
|lymphocyte|8/16|
|ovary|14/26|
|pancreas|14/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|9/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 422
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP62 Expression in NALM6 Cells: 6.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>