NUP85 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP85 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP85
  * **<color #00a2e8>Official Name</color>**: nucleoporin 85
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79902|79902]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BW27|Q9BW27]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP85&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP85|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/170285|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872). As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus (PubMed:12718872). The Nup107-160 complex seems to be required for spindle assembly during mitosis (PubMed:16807356). NUP85 is required for membrane clustering of CCL2-activated CCR2 (PubMed:15995708). Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade (PubMed:15995708). {ECO:0000269|PubMed:12718872, ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:16807356}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nucleopor Nup85|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pore outer ring|
|macrophage chemotaxis|
|macrophage migration|
|structural constituent of nuclear pore|
|lamellipodium assembly|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|lamellipodium organization|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism localization|
|multi-organism transport|
|regulation of glycolytic process|
|regulation of cellular response to heat|
|kinetochore|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|condensed chromosome kinetochore|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|protein import into nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|import into nucleus|
|viral transcription|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|spindle|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|nephron development|
|ribonucleoprotein complex localization|
|myeloid leukocyte migration|
|RNA export from nucleus|
|regulation of gene silencing|
|viral gene expression|
|protein import|
|leukocyte chemotaxis|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|regulation of generation of precursor metabolites and energy|
|protein localization to nucleus|
|nuclear envelope|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|cell chemotaxis|
|RNA localization|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|kidney development|
|renal system development|
|peptidyl-lysine modification|
|urogenital system development|
|leukocyte migration|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|chemotaxis|
|taxis|
|viral process|
|protein localization to organelle|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|cell migration|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|intracellular protein transport|
|localization of cell|
|cell motility|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.32|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.96|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.83|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.87|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.91|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.91|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.08|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zfand5|ZFAND5]]|0.484|
|[[:human genes:n:nup160|NUP160]]|0.478|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.473|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.467|
|[[:human genes:c:cdca3|CDCA3]]|0.463|
|[[:human genes:c:c14orf93|C14orf93]]|0.461|
|[[:human genes:d:ddx23|DDX23]]|0.46|
|[[:human genes:p:psmd3|PSMD3]]|0.458|
|[[:human genes:s:supt5h|SUPT5H]]|0.456|
|[[:human genes:v:vasn|VASN]]|0.454|
|[[:human genes:n:ndc1|NDC1]]|0.453|
|[[:human genes:s:sec13|SEC13]]|0.453|
|[[:human genes:p:prpf8|PRPF8]]|0.45|
|[[:human genes:c:copg1|COPG1]]|0.449|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.449|
|[[:human genes:p:psmb2|PSMB2]]|0.448|
|[[:human genes:p:ppfia4|PPFIA4]]|0.446|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.445|
|[[:human genes:r:rps2|RPS2]]|0.445|
|[[:human genes:d:dtl|DTL]]|0.443|
|[[:human genes:c:chd4|CHD4]]|0.439|
|[[:human genes:c:ccna2|CCNA2]]|0.437|
|[[:human genes:a:ahctf1|AHCTF1]]|0.436|
|[[:human genes:t:tfip11|TFIP11]]|0.435|
|[[:human genes:r:rnpc3|RNPC3]]|0.432|
|[[:human genes:c:cbwd3|CBWD3]]|0.432|
|[[:human genes:s:slc4a1|SLC4A1]]|0.431|
|[[:human genes:o:orc1|ORC1]]|0.43|
|[[:human genes:z:znf148|ZNF148]]|0.43|
|[[:human genes:c:cactin|CACTIN]]|0.428|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.427|
|[[:human genes:m:myo1h|MYO1H]]|0.427|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.427|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.424|
|[[:human genes:a:apc2|APC2]]|0.423|
|[[:human genes:c:cdc73|CDC73]]|0.422|
|[[:human genes:f:fbxw9|FBXW9]]|0.421|
|[[:human genes:r:ranbp2|RANBP2]]|0.421|
|[[:human genes:c:cbwd6|CBWD6]]|0.421|
|[[:human genes:t:tceb3c|TCEB3C]]|0.421|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.421|
|[[:human genes:h:hivep3|HIVEP3]]|0.419|
|[[:human genes:c:copa|COPA]]|0.418|
|[[:human genes:a:atp13a1|ATP13A1]]|0.415|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.414|
|[[:human genes:a:aqr|AQR]]|0.413|
|[[:human genes:c:cbwd5|CBWD5]]|0.413|
|[[:human genes:n:nupl1|NUPL1]]|0.411|
|[[:human genes:e:exosc9|EXOSC9]]|0.411|
|[[:human genes:c:cdc6|CDC6]]|0.411|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.41|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.409|
|[[:human genes:r:rad51|RAD51]]|0.408|
|[[:human genes:r:rps9|RPS9]]|0.408|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.408|
|[[:human genes:n:npipb5|NPIPB5]]|0.408|
|[[:human genes:s:slc6a17|SLC6A17]]|0.407|
|[[:human genes:p:psmc5|PSMC5]]|0.406|
|[[:human genes:p:psmd6|PSMD6]]|0.405|
|[[:human genes:m:med17|MED17]]|0.405|
|[[:human genes:s:srsf1|SRSF1]]|0.405|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.404|
|[[:human genes:s:ssh2|SSH2]]|0.404|
|[[:human genes:l:lad1|LAD1]]|0.404|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.403|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.403|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.403|
|[[:human genes:p:psmc1|PSMC1]]|0.402|
|[[:human genes:p:pan3|PAN3]]|0.401|
|[[:human genes:o:orc6|ORC6]]|0.401|
|[[:human genes:s:snrpa1|SNRPA1]]|0.401|
|[[:human genes:z:znf655|ZNF655]]|0.401|
|[[:human genes:n:nup153|NUP153]]|0.401|
|[[:human genes:p:polr2j3|POLR2J3]]|0.4|
|[[:human genes:c:cdk12|CDK12]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 713/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|19/21|
|liver|19/20|
|lung|72/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 376
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP85 Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>