NUP88 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP88 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP88
  * **<color #00a2e8>Official Name</color>**: nucleoporin 88
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4927|4927]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99567|Q99567]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP88&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP88|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602552|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of nuclear pore complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nup88|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal small subunit export from nucleus|
|ribosomal large subunit export from nucleus|
|ribosome localization|
|ribosomal subunit export from nucleus|
|rRNA-containing ribonucleoprotein complex export from nucleus|
|structural constituent of nuclear pore|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|transporter activity|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism transport|
|multi-organism localization|
|nuclear pore|
|regulation of cellular response to heat|
|regulation of glycolytic process|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|protein import into nucleus|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|viral transcription|
|import into nucleus|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|protein import|
|protein export from nucleus|
|mRNA transport|
|regulation of generation of precursor metabolites and energy|
|nuclear export|
|protein localization to nucleus|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|ribosome biogenesis|
|peptidyl-lysine modification|
|establishment of organelle localization|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|ribonucleoprotein complex biogenesis|
|organelle localization|
|mitotic cell cycle|
|viral process|
|regulation of cellular response to stress|
|protein localization to organelle|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|cell cycle|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.27|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.84|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.7|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.72|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.72|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.74|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.77|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.78|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.79|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.79|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.83|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.86|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.96|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|2|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2.01|
|[[:results:exp114|A-196 10μM R03 exp114]]|2.07|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.16|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2.23|
|[[:results:exp124|GSK343 3μM R03 exp124]]|2.29|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.29|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2.33|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|2.35|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|2.39|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|2.65|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|2.69|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 425/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|21/28|
|bone|15/26|
|breast|25/33|
|central nervous system|23/56|
|cervix|1/4|
|colorectal|12/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|10/21|
|liver|16/20|
|lung|38/75|
|lymphocyte|8/16|
|ovary|19/26|
|pancreas|17/24|
|peripheral nervous system|6/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|15/24|
|soft tissue|7/9|
|thyroid|0/2|
|upper aerodigestive|9/22|
|urinary tract|20/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1074
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP88 Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>