NUPL2 [The Human Chemical-Genetic Interaction Map Project]

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======= NUPL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP42
  * **<color #00a2e8>Official Name</color>**: nucleoporin 42
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11097|11097]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15504|O15504]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUPL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUPL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619998|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. {ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:16000379}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear export signal receptor activity|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism transport|
|multi-organism localization|
|nuclear pore|
|regulation of cellular response to heat|
|regulation of glycolytic process|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|viral transcription|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|protein export from nucleus|
|mRNA transport|
|regulation of generation of precursor metabolites and energy|
|nuclear export|
|nuclear envelope|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|peptidyl-lysine modification|
|regulation of small molecule metabolic process|
|viral process|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|RNA binding|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.82|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.81|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.7|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.81|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.86|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.15|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.2|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.39|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.5|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nxt1|NXT1]]|0.585|
|[[:human genes:h:hars|HARS]]|0.58|
|[[:human genes:e:eny2|ENY2]]|0.535|
|[[:human genes:c:csnk2b|CSNK2B]]|0.499|
|[[:human genes:c:cycs|CYCS]]|0.495|
|[[:human genes:t:triap1|TRIAP1]]|0.476|
|[[:human genes:t:thoc6|THOC6]]|0.464|
|[[:human genes:h:hccs|HCCS]]|0.46|
|[[:human genes:a:atp5j|ATP5J]]|0.457|
|[[:human genes:c:casp9|CASP9]]|0.455|
|[[:human genes:h:hspd1|HSPD1]]|0.454|
|[[:human genes:m:meaf6|MEAF6]]|0.453|
|[[:human genes:r:rptor|RPTOR]]|0.445|
|[[:human genes:m:mtor|MTOR]]|0.445|
|[[:human genes:g:gfpt1|GFPT1]]|0.44|
|[[:human genes:a:alg5|ALG5]]|0.438|
|[[:human genes:p:plaa|PLAA]]|0.438|
|[[:human genes:d:dnajc3|DNAJC3]]|0.437|
|[[:human genes:r:rnmt|RNMT]]|0.434|
|[[:human genes:n:nup50|NUP50]]|0.432|
|[[:human genes:m:mapk14|MAPK14]]|0.432|
|[[:human genes:a:apaf1|APAF1]]|0.43|
|[[:human genes:d:dpagt1|DPAGT1]]|0.425|
|[[:human genes:g:gmppb|GMPPB]]|0.424|
|[[:human genes:p:pmm2|PMM2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2683
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUPL2 Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>