NUS1 [The Human Chemical-Genetic Interaction Map Project]

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======= NUS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUS1
  * **<color #00a2e8>Official Name</color>**: NUS1 dehydrodolichyl diphosphate synthase subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116150|116150]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96E22|Q96E22]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610463|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly expressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. {ECO:0000269|PubMed:16835300, ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prenyltransf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dolichol biosynthetic process|
|dehydrodolichyl diphosphate synthase complex|
|prenyltransferase activity|
|dehydrodolichyl diphosphate synthase activity|
|polyprenol biosynthetic process|
|dolichol metabolic process|
|dolichyl diphosphate metabolic process|
|dolichyl diphosphate biosynthetic process|
|polyprenol metabolic process|
|regulation of intracellular sterol transport|
|regulation of intracellular cholesterol transport|
|regulation of intracellular lipid transport|
|dolichol-linked oligosaccharide biosynthetic process|
|vascular endothelial growth factor signaling pathway|
|oligosaccharide-lipid intermediate biosynthetic process|
|positive regulation of nitric-oxide synthase activity|
|protein mannosylation|
|positive regulation of monooxygenase activity|
|isoprenoid biosynthetic process|
|mannosylation|
|cellular response to vascular endothelial growth factor stimulus|
|regulation of nitric-oxide synthase activity|
|regulation of cholesterol transport|
|regulation of sterol transport|
|positive regulation of oxidoreductase activity|
|regulation of monooxygenase activity|
|positive regulation of blood vessel endothelial cell migration|
|protein N-linked glycosylation|
|cholesterol homeostasis|
|sterol homeostasis|
|regulation of blood vessel endothelial cell migration|
|regulation of oxidoreductase activity|
|positive regulation of endothelial cell migration|
|regulation of lipid transport|
|alcohol biosynthetic process|
|lipid homeostasis|
|regulation of lipid localization|
|isoprenoid metabolic process|
|positive regulation of epithelial cell migration|
|regulation of endothelial cell migration|
|organic hydroxy compound biosynthetic process|
|regulation of epithelial cell migration|
|phospholipid biosynthetic process|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|alcohol metabolic process|
|angiogenesis|
|glycoprotein biosynthetic process|
|regulation of intracellular transport|
|phospholipid metabolic process|
|glycoprotein metabolic process|
|blood vessel morphogenesis|
|organic hydroxy compound metabolic process|
|blood vessel development|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|positive regulation of cell motility|
|response to growth factor|
|organophosphate biosynthetic process|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|tube morphogenesis|
|enzyme linked receptor protein signaling pathway|
|tube development|
|regulation of cell migration|
|circulatory system development|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|regulation of locomotion|
|regulation of cellular component movement|
|carbohydrate derivative metabolic process|
|chemical homeostasis|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|homeostatic process|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.7|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.72|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.78|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.78|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.81|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.87|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.92|
|[[:results:exp100|NFN1 1μM R03 exp100]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pnisr|PNISR]]|0.432|
|[[:human genes:c:capsl|CAPSL]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 692/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/26|
|breast|31/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|20/21|
|liver|20/20|
|lung|69/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|22/24|
|peripheral nervous system|13/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 557
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUS1 Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>