NXF1 [The Human Chemical-Genetic Interaction Map Project]

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======= NXF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NXF1
  * **<color #00a2e8>Official Name</color>**: nuclear RNA export factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10482|10482]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBU9|Q9UBU9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NXF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NXF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602647|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:9660949}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tap-RNA bind|
|NTF2|
|TAP C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear inclusion body|
|transcription export complex|
|poly(A)+ mRNA export from nucleus|
|nuclear pore|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|mRNA binding|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|nuclear speck|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|intracellular protein transport|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.94|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.79|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.7|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.73|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.74|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.8|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.83|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.92|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.03|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.08|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2.3|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.607|
|[[:human genes:c:cln6|CLN6]]|0.445|
|[[:human genes:n:napa|NAPA]]|0.416|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.413|
|[[:human genes:t:tfip11|TFIP11]]|0.408|
|[[:human genes:n:nol10|NOL10]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 523/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|22/28|
|blood|25/28|
|bone|13/26|
|breast|24/33|
|central nervous system|38/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|11/16|
|kidney|12/21|
|liver|14/20|
|lung|49/75|
|lymphocyte|11/16|
|ovary|21/26|
|pancreas|18/24|
|peripheral nervous system|11/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|20/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 653
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NXF1 Expression in NALM6 Cells: 6.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>