NXT1 [The Human Chemical-Genetic Interaction Map Project]

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======= NXT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NXT1
  * **<color #00a2e8>Official Name</color>**: nuclear transport factor 2 like export factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29107|29107]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKK6|Q9UKK6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NXT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NXT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605811|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5. {ECO:0000269|PubMed:10567585, ECO:0000269|PubMed:10848583, ECO:0000269|PubMed:11259602, ECO:0000269|PubMed:19165146}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NTF2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pore central transport channel|
|Ran GTPase binding|
|nuclear pore|
|protein import into nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|import into nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|protein import|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|protein localization to nucleus|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|nuclear speck|
|establishment of protein localization to organelle|
|protein localization to organelle|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.87|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.81|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.83|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.83|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.93|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.98|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.01|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.1|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.12|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.28|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.48|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.53|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.77|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.03|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3.03|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|4.12|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|5.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eny2|ENY2]]|0.642|
|[[:human genes:h:hars|HARS]]|0.619|
|[[:human genes:n:nupl2|NUPL2]]|0.585|
|[[:human genes:m:meaf6|MEAF6]]|0.567|
|[[:human genes:c:csnk2b|CSNK2B]]|0.538|
|[[:human genes:t:thoc6|THOC6]]|0.535|
|[[:human genes:a:abcf3|ABCF3]]|0.533|
|[[:human genes:u:ube2k|UBE2K]]|0.516|
|[[:human genes:g:gfpt1|GFPT1]]|0.511|
|[[:human genes:c:casp9|CASP9]]|0.503|
|[[:human genes:n:nup50|NUP50]]|0.493|
|[[:human genes:p:plaa|PLAA]]|0.483|
|[[:human genes:h:hccs|HCCS]]|0.481|
|[[:human genes:c:cycs|CYCS]]|0.48|
|[[:human genes:d:diablo|DIABLO]]|0.475|
|[[:human genes:h:hspd1|HSPD1]]|0.474|
|[[:human genes:g:gabpa|GABPA]]|0.471|
|[[:human genes:a:alg5|ALG5]]|0.47|
|[[:human genes:d:ddx19a|DDX19A]]|0.466|
|[[:human genes:t:tle4|TLE4]]|0.453|
|[[:human genes:d:dnajc3|DNAJC3]]|0.452|
|[[:human genes:t:timm23b|TIMM23B]]|0.445|
|[[:human genes:m:mapk14|MAPK14]]|0.445|
|[[:human genes:c:ccdc101|CCDC101]]|0.442|
|[[:human genes:a:apaf1|APAF1]]|0.44|
|[[:human genes:u:ube2l3|UBE2L3]]|0.44|
|[[:human genes:u:uap1|UAP1]]|0.437|
|[[:human genes:a:atp5j|ATP5J]]|0.436|
|[[:human genes:r:rptor|RPTOR]]|0.431|
|[[:human genes:s:sec16a|SEC16A]]|0.428|
|[[:human genes:g:gmppb|GMPPB]]|0.426|
|[[:human genes:s:suv420h1|SUV420H1]]|0.424|
|[[:human genes:t:triap1|TRIAP1]]|0.424|
|[[:human genes:p:pmm2|PMM2]]|0.424|
|[[:human genes:r:rnmt|RNMT]]|0.423|
|[[:human genes:h:hhex|HHEX]]|0.423|
|[[:human genes:u:ubqln1|UBQLN1]]|0.421|
|[[:human genes:o:otud5|OTUD5]]|0.42|
|[[:human genes:a:aars|AARS]]|0.418|
|[[:human genes:d:derl2|DERL2]]|0.418|
|[[:human genes:m:march5|MARCH5]]|0.417|
|[[:human genes:u:uba3|UBA3]]|0.412|
|[[:human genes:o:opa1|OPA1]]|0.41|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.409|
|[[:human genes:s:spcs2|SPCS2]]|0.406|
|[[:human genes:d:derl1|DERL1]]|0.406|
|[[:human genes:m:mfn1|MFN1]]|0.404|
|[[:human genes:t:tbp|TBP]]|0.403|
|[[:human genes:a:alg2|ALG2]]|0.4|
|[[:human genes:t:timm13|TIMM13]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 94/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|1/28|
|bone|1/26|
|breast|4/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|4/20|
|lung|8/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|6/24|
|peripheral nervous system|8/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1567
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NXT1 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>