OGFR [The Human Chemical-Genetic Interaction Map Project]

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======= OGFR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OGFR
  * **<color #00a2e8>Official Name</color>**: opioid growth factor receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11054|11054]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZT2|Q9NZT2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OGFR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OGFR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606459|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OGFr III|
|OGFr N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|opioid receptor activity|
|opioid receptor signaling pathway|
|regulation of cell growth|
|cellular component|
|regulation of growth|
|G protein-coupled receptor signaling pathway|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-2.08|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.94|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.73|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.81|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vasn|VASN]]|0.551|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.541|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.523|
|[[:human genes:p:polr2j3|POLR2J3]]|0.515|
|[[:human genes:v:vps54|VPS54]]|0.513|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.511|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.509|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.504|
|[[:human genes:p:psma6|PSMA6]]|0.504|
|[[:human genes:s:smg1|SMG1]]|0.503|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.5|
|[[:human genes:t:terf1|TERF1]]|0.495|
|[[:human genes:k:kif3c|KIF3C]]|0.487|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.485|
|[[:human genes:r:rps12|RPS12]]|0.484|
|[[:human genes:o:orc1|ORC1]]|0.481|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.481|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.481|
|[[:human genes:p:pcf11|PCF11]]|0.48|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.48|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.48|
|[[:human genes:s:supt6h|SUPT6H]]|0.48|
|[[:human genes:c:cbwd3|CBWD3]]|0.48|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.479|
|[[:human genes:u:upf1|UPF1]]|0.476|
|[[:human genes:p:polr2d|POLR2D]]|0.476|
|[[:human genes:d:disp2|DISP2]]|0.475|
|[[:human genes:c:chd4|CHD4]]|0.475|
|[[:human genes:t:twistnb|TWISTNB]]|0.474|
|[[:human genes:n:nol10|NOL10]]|0.468|
|[[:human genes:t:ttc1|TTC1]]|0.467|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.465|
|[[:human genes:c:chchd3|CHCHD3]]|0.465|
|[[:human genes:t:tfip11|TFIP11]]|0.462|
|[[:human genes:f:fam86b2|FAM86B2]]|0.461|
|[[:human genes:c:ccna2|CCNA2]]|0.46|
|[[:human genes:c:cbwd5|CBWD5]]|0.457|
|[[:human genes:a:aqr|AQR]]|0.457|
|[[:human genes:r:rpsa|RPSA]]|0.456|
|[[:human genes:z:zfand5|ZFAND5]]|0.455|
|[[:human genes:m:med29|MED29]]|0.454|
|[[:human genes:z:znf106|ZNF106]]|0.454|
|[[:human genes:p:psmd7|PSMD7]]|0.453|
|[[:human genes:n:npipb5|NPIPB5]]|0.453|
|[[:human genes:p:pan2|PAN2]]|0.452|
|[[:human genes:e:exosc5|EXOSC5]]|0.452|
|[[:human genes:a:ankle1|ANKLE1]]|0.451|
|[[:human genes:p:psmd3|PSMD3]]|0.451|
|[[:human genes:c:cdc45|CDC45]]|0.451|
|[[:human genes:t:tceb3c|TCEB3C]]|0.45|
|[[:human genes:s:supt5h|SUPT5H]]|0.45|
|[[:human genes:s:smg5|SMG5]]|0.448|
|[[:human genes:r:rbbp5|RBBP5]]|0.446|
|[[:human genes:m:med17|MED17]]|0.446|
|[[:human genes:s:stil|STIL]]|0.444|
|[[:human genes:r:rps14|RPS14]]|0.444|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.444|
|[[:human genes:c:cbwd6|CBWD6]]|0.444|
|[[:human genes:a:akirin2|AKIRIN2]]|0.442|
|[[:human genes:p:psmd6|PSMD6]]|0.442|
|[[:human genes:a:aatf|AATF]]|0.442|
|[[:human genes:u:utp20|UTP20]]|0.441|
|[[:human genes:g:golga6b|GOLGA6B]]|0.44|
|[[:human genes:p:psmb4|PSMB4]]|0.44|
|[[:human genes:m:mt1e|MT1E]]|0.437|
|[[:human genes:p:psmd1|PSMD1]]|0.437|
|[[:human genes:s:snrpa1|SNRPA1]]|0.436|
|[[:human genes:c:cmya5|CMYA5]]|0.436|
|[[:human genes:n:nup54|NUP54]]|0.436|
|[[:human genes:k:kctd17|KCTD17]]|0.436|
|[[:human genes:p:polr1a|POLR1A]]|0.435|
|[[:human genes:m:myb|MYB]]|0.435|
|[[:human genes:p:psmc6|PSMC6]]|0.435|
|[[:human genes:c:c14orf93|C14orf93]]|0.435|
|[[:human genes:r:rnf121|RNF121]]|0.435|
|[[:human genes:e:exosc9|EXOSC9]]|0.434|
|[[:human genes:d:ddtl|DDTL]]|0.434|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.434|
|[[:human genes:n:nup107|NUP107]]|0.433|
|[[:human genes:p:pwp2|PWP2]]|0.433|
|[[:human genes:t:trappc8|TRAPPC8]]|0.432|
|[[:human genes:n:nol12|NOL12]]|0.431|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.431|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.431|
|[[:human genes:c:cdca3|CDCA3]]|0.431|
|[[:human genes:g:golga6a|GOLGA6A]]|0.429|
|[[:human genes:r:rad51|RAD51]]|0.429|
|[[:human genes:r:rps2|RPS2]]|0.429|
|[[:human genes:a:arcn1|ARCN1]]|0.429|
|[[:human genes:p:pola1|POLA1]]|0.429|
|[[:human genes:p:plk4|PLK4]]|0.426|
|[[:human genes:m:mbtd1|MBTD1]]|0.426|
|[[:human genes:p:psmd13|PSMD13]]|0.426|
|[[:human genes:o:orc6|ORC6]]|0.426|
|[[:human genes:p:psmd11|PSMD11]]|0.426|
|[[:human genes:k:kpnb1|KPNB1]]|0.426|
|[[:human genes:h:hspa5|HSPA5]]|0.425|
|[[:human genes:p:psmc2|PSMC2]]|0.425|
|[[:human genes:p:ppp1r15b|PPP1R15B]]|0.424|
|[[:human genes:s:syt9|SYT9]]|0.424|
|[[:human genes:s:slc6a17|SLC6A17]]|0.424|
|[[:human genes:r:riok2|RIOK2]]|0.424|
|[[:human genes:r:rad21|RAD21]]|0.424|
|[[:human genes:s:smg7|SMG7]]|0.422|
|[[:human genes:a:aaas|AAAS]]|0.422|
|[[:human genes:r:rps28|RPS28]]|0.421|
|[[:human genes:i:igfn1|IGFN1]]|0.421|
|[[:human genes:t:timeless|TIMELESS]]|0.42|
|[[:human genes:d:dync1i2|DYNC1I2]]|0.42|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.419|
|[[:human genes:p:psmb1|PSMB1]]|0.419|
|[[:human genes:s:slc4a1|SLC4A1]]|0.419|
|[[:human genes:h:h3f3a|H3F3A]]|0.419|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.419|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.418|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.418|
|[[:human genes:w:wdr43|WDR43]]|0.418|
|[[:human genes:c:cep192|CEP192]]|0.417|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.417|
|[[:human genes:t:tyms|TYMS]]|0.416|
|[[:human genes:f:fut11|FUT11]]|0.416|
|[[:human genes:n:nbpf10|NBPF10]]|0.416|
|[[:human genes:m:med14|MED14]]|0.416|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.414|
|[[:human genes:r:rpl7a|RPL7A]]|0.414|
|[[:human genes:y:ythdc1|YTHDC1]]|0.414|
|[[:human genes:u:uspl1|USPL1]]|0.413|
|[[:human genes:d:dtl|DTL]]|0.412|
|[[:human genes:n:nup205|NUP205]]|0.411|
|[[:human genes:r:rfxank|RFXANK]]|0.41|
|[[:human genes:a:acsf2|ACSF2]]|0.41|
|[[:human genes:c:copb1|COPB1]]|0.409|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.409|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.408|
|[[:human genes:p:pola2|POLA2]]|0.407|
|[[:human genes:h:hap1|HAP1]]|0.407|
|[[:human genes:c:cope|COPE]]|0.407|
|[[:human genes:t:terf2|TERF2]]|0.407|
|[[:human genes:a:actl7a|ACTL7A]]|0.406|
|[[:human genes:s:sec13|SEC13]]|0.406|
|[[:human genes:r:ranbp2|RANBP2]]|0.405|
|[[:human genes:g:gid4|GID4]]|0.405|
|[[:human genes:x:xab2|XAB2]]|0.404|
|[[:human genes:p:pbxip1|PBXIP1]]|0.404|
|[[:human genes:t:top1mt|TOP1MT]]|0.403|
|[[:human genes:t:ticrr|TICRR]]|0.403|
|[[:human genes:n:nop16|NOP16]]|0.403|
|[[:human genes:r:rpl35|RPL35]]|0.403|
|[[:human genes:s:s1pr4|S1PR4]]|0.402|
|[[:human genes:g:golga8o|GOLGA8O]]|0.402|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.402|
|[[:human genes:s:scaf1|SCAF1]]|0.401|
|[[:human genes:t:tspy1|TSPY1]]|0.401|
|[[:human genes:f:fbxl19|FBXL19]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1942
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OGFR Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>