OGG1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= OGG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OGG1
  * **<color #00a2e8>Official Name</color>**: 8-oxoguanine DNA glycosylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4968|4968]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15527|O15527]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OGG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OGG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601982|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HhH-GPD|
|OGG N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of double-strand break repair via single-strand annealing|
|8-oxo-7,8-dihydroguanine DNA N-glycosylase activity|
|oxidized purine nucleobase lesion DNA N-glycosylase activity|
|depurination|
|oxidized purine DNA binding|
|depyrimidination|
|base-excision repair, AP site formation|
|class I DNA-(apurinic or apyrimidinic site) endonuclease activity|
|response to folic acid|
|pyrimidine deoxyribonucleotide catabolic process|
|pyrimidine nucleotide catabolic process|
|pyrimidine deoxyribonucleotide metabolic process|
|deoxyribonucleotide catabolic process|
|deoxyribose phosphate catabolic process|
|2-deoxyribonucleotide metabolic process|
|negative regulation of double-strand break repair|
|negative regulation of DNA repair|
|deoxyribose phosphate metabolic process|
|deoxyribonucleotide metabolic process|
|cellular response to cadmium ion|
|endonuclease activity|
|base-excision repair|
|nucleotide-excision repair, DNA incision|
|pyrimidine-containing compound catabolic process|
|damaged DNA binding|
|pyrimidine nucleotide metabolic process|
|response to cadmium ion|
|nucleotide catabolic process|
|acute inflammatory response|
|nucleoside phosphate catabolic process|
|regulation of double-strand break repair|
|negative regulation of response to DNA damage stimulus|
|response to vitamin|
|DNA modification|
|nucleobase-containing small molecule biosynthetic process|
|pyrimidine-containing compound metabolic process|
|nuclear matrix|
|nucleotide-excision repair|
|negative regulation of DNA metabolic process|
|regulation of DNA repair|
|response to ethanol|
|organophosphate catabolic process|
|response to estradiol|
|carbohydrate derivative catabolic process|
|cellular response to metal ion|
|response to nutrient|
|regulation of response to DNA damage stimulus|
|cellular response to inorganic substance|
|response to alcohol|
|microtubule binding|
|aging|
|nucleic acid phosphodiester bond hydrolysis|
|response to antibiotic|
|response to light stimulus|
|response to acid chemical|
|regulation of DNA metabolic process|
|response to metal ion|
|nucleobase-containing compound catabolic process|
|response to oxidative stress|
|nuclear speck|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|response to radiation|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|inflammatory response|
|response to nutrient levels|
|response to toxic substance|
|DNA repair|
|response to extracellular stimulus|
|response to inorganic substance|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|protein-containing complex|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|response to lipid|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|negative regulation of cell death|
|response to organonitrogen compound|
|response to drug|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|defense response|
|negative regulation of nucleobase-containing compound metabolic process|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17191
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OGG1 Expression in NALM6 Cells: 4.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>