OLFM1 [The Human Chemical-Genetic Interaction Map Project]

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======= OLFM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OLFM1
  * **<color #00a2e8>Official Name</color>**: olfactomedin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10439|10439]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99784|Q99784]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OLFM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OLFM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605366|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity). {ECO:0000250|UniProtKB:O88998, ECO:0000250|UniProtKB:Q9IAK4}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OLF|
|Noelin-1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuronal signal transduction|
|atrioventricular valve formation|
|heart valve formation|
|atrioventricular valve morphogenesis|
|atrioventricular valve development|
|axonal growth cone|
|cardiac epithelial to mesenchymal transition|
|positive regulation of epithelial to mesenchymal transition|
|heart valve morphogenesis|
|heart valve development|
|epithelial to mesenchymal transition|
|cell|
|regulation of epithelial to mesenchymal transition|
|regulation of axon extension|
|regulation of extent of cell growth|
|perikaryon|
|mesenchymal cell differentiation|
|regulation of cell size|
|regulation of axonogenesis|
|mesenchyme development|
|heart morphogenesis|
|synapse|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|regulation of developmental growth|
|neuronal cell body|
|regulation of cellular component size|
|regulation of cell growth|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|heart development|
|cell junction|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|regulation of neurogenesis|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|endoplasmic reticulum|
|regulation of anatomical structure morphogenesis|
|positive regulation of developmental process|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|neurogenesis|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13083
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OLFM1 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>