OMA1 [The Human Chemical-Genetic Interaction Map Project]

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======= OMA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OMA1
  * **<color #00a2e8>Official Name</color>**: OMA1 zinc metallopeptidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=115209|115209]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96E52|Q96E52]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OMA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OMA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617081|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. {ECO:0000250|UniProtKB:Q9D8H7, ECO:0000269|PubMed:20038677}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M48|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mitochondrial fusion|
|regulation of mitochondrial fusion|
|mitochondrial protein processing|
|diet induced thermogenesis|
|adaptive thermogenesis|
|response to dietary excess|
|protein quality control for misfolded or incompletely synthesized proteins|
|cristae formation|
|energy homeostasis|
|inner mitochondrial membrane organization|
|negative regulation of mitochondrion organization|
|positive regulation of cold-induced thermogenesis|
|mitochondrial membrane|
|metalloendopeptidase activity|
|glucose metabolic process|
|mitochondrial membrane organization|
|regulation of cold-induced thermogenesis|
|hexose metabolic process|
|protein processing|
|regulation of mitochondrion organization|
|monosaccharide metabolic process|
|protein maturation|
|multicellular organismal homeostasis|
|negative regulation of organelle organization|
|mitochondrial inner membrane|
|mitochondrion organization|
|carbohydrate metabolic process|
|response to nutrient levels|
|response to extracellular stimulus|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|negative regulation of cellular component organization|
|membrane organization|
|cellular macromolecule catabolic process|
|negative regulation of developmental process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|lipid metabolic process|
|proteolysis|
|regulation of organelle organization|
|regulation of apoptotic process|
|regulation of programmed cell death|
|homeostatic process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.04|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.76|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.78|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.78|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.8|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.82|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.84|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.97|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.27|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.95|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|3.25|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|3.25|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|8.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cluh|CLUH]]|0.524|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.486|
|[[:human genes:t:timm21|TIMM21]]|0.472|
|[[:human genes:n:ndufa1|NDUFA1]]|0.453|
|[[:human genes:e:eif2ak1|EIF2AK1]]|0.419|
|[[:human genes:p:pet117|PET117]]|0.416|
|[[:human genes:n:ndufa10|NDUFA10]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4904
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OMA1 Expression in NALM6 Cells: 4.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>