OPRD1 [The Human Chemical-Genetic Interaction Map Project]

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======= OPRD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OPRD1
  * **<color #00a2e8>Official Name</color>**: opioid receptor delta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4985|4985]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41143|P41143]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OPRD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OPRD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165195|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srx|
|7TM GPCR Srsx|
|7TM GPCR Srv|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enkephalin receptor activity|
|spine apparatus|
|neuronal dense core vesicle|
|receptor serine/threonine kinase binding|
|opioid receptor activity|
|opioid receptor signaling pathway|
|negative regulation of protein oligomerization|
|positive regulation of CREB transcription factor activity|
|neuropeptide binding|
|eating behavior|
|dendrite membrane|
|integral component of synaptic vesicle membrane|
|intrinsic component of plasma membrane|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|regulation of protein oligomerization|
|integral component of postsynaptic density membrane|
|peptide binding|
|axon terminus|
|integral component of presynaptic membrane|
|regulation of mitochondrial membrane potential|
|adult locomotory behavior|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|feeding behavior|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|positive regulation of peptidyl-serine phosphorylation|
|neuropeptide signaling pathway|
|negative regulation of protein complex assembly|
|regulation of peptidyl-serine phosphorylation|
|regulation of nervous system process|
|adult behavior|
|cellular response to hypoxia|
|locomotory behavior|
|cellular response to decreased oxygen levels|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cellular response to toxic substance|
|cellular response to oxygen levels|
|membrane raft|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|positive regulation of DNA-binding transcription factor activity|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|regulation of metal ion transport|
|regulation of DNA-binding transcription factor activity|
|regulation of membrane potential|
|regulation of protein complex assembly|
|cellular response to growth factor stimulus|
|response to toxic substance|
|response to growth factor|
|behavior|
|regulation of system process|
|cytokine-mediated signaling pathway|
|regulation of ion transport|
|negative regulation of cellular component organization|
|G protein-coupled receptor activity|
|regulation of cellular component biogenesis|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12742
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OPRD1 Expression in NALM6 Cells: 3.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>