OR10G3 [The Human Chemical-Genetic Interaction Map Project]

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======= OR10G3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OR10G3
  * **<color #00a2e8>Official Name</color>**: olfactory receptor family 10 subfamily G member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26533|26533]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NGC4|Q8NGC4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OR10G3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OR10G3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Odorant receptor. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|olfactory receptor activity|
|detection of chemical stimulus involved in sensory perception of smell|
|sensory perception of smell|
|detection of chemical stimulus involved in sensory perception|
|detection of chemical stimulus|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|detection of stimulus|
|G protein-coupled receptor activity|
|sensory perception|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.71|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.27|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.7|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.7|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.73|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.78|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.89|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.89|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.9|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.9|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.9|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|2.11|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.31|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|2.41|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|2.69|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:ankle2|ANKLE2]]|0.514|
|[[:human genes:t:twistnb|TWISTNB]]|0.503|
|[[:human genes:p:psmb4|PSMB4]]|0.491|
|[[:human genes:c:chd4|CHD4]]|0.49|
|[[:human genes:c:c14orf93|C14orf93]]|0.485|
|[[:human genes:n:nupl1|NUPL1]]|0.475|
|[[:human genes:r:rbbp5|RBBP5]]|0.474|
|[[:human genes:l:lrr1|LRR1]]|0.474|
|[[:human genes:t:tfip11|TFIP11]]|0.473|
|[[:human genes:r:ranbp2|RANBP2]]|0.472|
|[[:human genes:d:ddtl|DDTL]]|0.471|
|[[:human genes:r:rpl35|RPL35]]|0.47|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.468|
|[[:human genes:c:cbwd5|CBWD5]]|0.466|
|[[:human genes:c:cbwd3|CBWD3]]|0.464|
|[[:human genes:p:psmd11|PSMD11]]|0.463|
|[[:human genes:s:stil|STIL]]|0.462|
|[[:human genes:a:aamp|AAMP]]|0.462|
|[[:human genes:v:vasn|VASN]]|0.46|
|[[:human genes:r:rbm39|RBM39]]|0.457|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.457|
|[[:human genes:c:cbwd6|CBWD6]]|0.456|
|[[:human genes:t:tceb3c|TCEB3C]]|0.456|
|[[:human genes:s:supt5h|SUPT5H]]|0.454|
|[[:human genes:i:ik|IK]]|0.453|
|[[:human genes:c:cep192|CEP192]]|0.453|
|[[:human genes:c:cdc45|CDC45]]|0.453|
|[[:human genes:s:sult2b1|SULT2B1]]|0.453|
|[[:human genes:u:utp3|UTP3]]|0.453|
|[[:human genes:s:sap30bp|SAP30BP]]|0.452|
|[[:human genes:m:myo1h|MYO1H]]|0.451|
|[[:human genes:s:syt9|SYT9]]|0.45|
|[[:human genes:t:ticrr|TICRR]]|0.449|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.448|
|[[:human genes:r:rps2|RPS2]]|0.448|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.446|
|[[:human genes:p:psma6|PSMA6]]|0.445|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.443|
|[[:human genes:c:copa|COPA]]|0.442|
|[[:human genes:k:krt78|KRT78]]|0.441|
|[[:human genes:n:npipb5|NPIPB5]]|0.441|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.441|
|[[:human genes:n:nol8|NOL8]]|0.439|
|[[:human genes:f:fam86b2|FAM86B2]]|0.437|
|[[:human genes:s:slc4a1|SLC4A1]]|0.437|
|[[:human genes:t:tgm5|TGM5]]|0.434|
|[[:human genes:t:tspy8|TSPY8]]|0.432|
|[[:human genes:o:orc1|ORC1]]|0.431|
|[[:human genes:a:akirin2|AKIRIN2]]|0.43|
|[[:human genes:c:cactin|CACTIN]]|0.43|
|[[:human genes:f:fam160a1|FAM160A1]]|0.429|
|[[:human genes:z:znf106|ZNF106]]|0.429|
|[[:human genes:u:ubap1|UBAP1]]|0.428|
|[[:human genes:s:snip1|SNIP1]]|0.428|
|[[:human genes:r:rad21|RAD21]]|0.426|
|[[:human genes:c:col2a1|COL2A1]]|0.424|
|[[:human genes:i:iscu|ISCU]]|0.424|
|[[:human genes:p:psmc1|PSMC1]]|0.423|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.423|
|[[:human genes:n:nol10|NOL10]]|0.423|
|[[:human genes:d:dtl|DTL]]|0.422|
|[[:human genes:h:hap1|HAP1]]|0.422|
|[[:human genes:x:xylt2|XYLT2]]|0.42|
|[[:human genes:a:arcn1|ARCN1]]|0.419|
|[[:human genes:r:rpl34|RPL34]]|0.419|
|[[:human genes:p:parp3|PARP3]]|0.418|
|[[:human genes:c:ccna2|CCNA2]]|0.417|
|[[:human genes:p:pola1|POLA1]]|0.417|
|[[:human genes:o:orc6|ORC6]]|0.416|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.416|
|[[:human genes:c:copz1|COPZ1]]|0.416|
|[[:human genes:r:rps28|RPS28]]|0.415|
|[[:human genes:e:exosc9|EXOSC9]]|0.415|
|[[:human genes:d:dock6|DOCK6]]|0.414|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.414|
|[[:human genes:f:fam231c|FAM231C]]|0.413|
|[[:human genes:s:supt6h|SUPT6H]]|0.413|
|[[:human genes:f:fam231a|FAM231A]]|0.413|
|[[:human genes:c:cdc73|CDC73]]|0.412|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.412|
|[[:human genes:k:kctd17|KCTD17]]|0.412|
|[[:human genes:f:fbxw9|FBXW9]]|0.412|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.411|
|[[:human genes:c:copb1|COPB1]]|0.411|
|[[:human genes:t:thoc1|THOC1]]|0.41|
|[[:human genes:p:pcf11|PCF11]]|0.409|
|[[:human genes:u:utp20|UTP20]]|0.409|
|[[:human genes:c:chaf1a|CHAF1A]]|0.409|
|[[:human genes:p:prpf8|PRPF8]]|0.409|
|[[:human genes:n:nbpf10|NBPF10]]|0.409|
|[[:human genes:s:sf3a3|SF3A3]]|0.407|
|[[:human genes:m:mt1e|MT1E]]|0.407|
|[[:human genes:p:psmc6|PSMC6]]|0.405|
|[[:human genes:g:golga8o|GOLGA8O]]|0.404|
|[[:human genes:t:top1mt|TOP1MT]]|0.403|
|[[:human genes:n:nop16|NOP16]]|0.403|
|[[:human genes:e:egr2|EGR2]]|0.402|
|[[:human genes:r:rpl8|RPL8]]|0.402|
|[[:human genes:d:dnm2|DNM2]]|0.401|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.401|
|[[:human genes:e:exosc6|EXOSC6]]|0.401|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.4|
|[[:human genes:c:cdca5|CDCA5]]|0.4|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.4|
|[[:human genes:p:plk1|PLK1]]|0.4|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1831
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OR10G3 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>