OR51E2 [The Human Chemical-Genetic Interaction Map Project]

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======= OR51E2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OR51E2
  * **<color #00a2e8>Official Name</color>**: olfactory receptor family 51 subfamily E member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81285|81285]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H255|Q9H255]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OR51E2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OR51E2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611268|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). May also function as an olfactory receptor being activated by beta-ionone (PubMed:19389702). {ECO:0000269|PubMed:19389702, ECO:0000269|PubMed:23401498}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of renin secretion into blood stream|
|melanocyte proliferation|
|intracellular organelle|
|regulation of renin secretion into blood stream|
|melanocyte differentiation|
|positive regulation of cAMP-mediated signaling|
|pigment cell differentiation|
|regulation of renal system process|
|positive regulation of blood pressure|
|developmental pigmentation|
|regulation of endocrine process|
|regulation of cAMP-mediated signaling|
|steroid hormone receptor activity|
|cellular response to fatty acid|
|positive regulation of blood circulation|
|response to fatty acid|
|epithelial cell proliferation|
|pigmentation|
|regulation of systemic arterial blood pressure|
|steroid hormone mediated signaling pathway|
|early endosome membrane|
|hormone-mediated signaling pathway|
|regulation of blood pressure|
|cellular response to steroid hormone stimulus|
|signaling receptor activity|
|cellular response to acid chemical|
|positive regulation of protein secretion|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|response to steroid hormone|
|response to acid chemical|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|detection of chemical stimulus involved in sensory perception of smell|
|olfactory receptor activity|
|positive regulation of establishment of protein localization|
|sensory perception of smell|
|regulation of protein secretion|
|detection of chemical stimulus involved in sensory perception|
|regulation of peptide secretion|
|cellular response to lipid|
|detection of chemical stimulus|
|sensory perception of chemical stimulus|
|cellular response to organic cyclic compound|
|detection of stimulus involved in sensory perception|
|cell population proliferation|
|regulation of system process|
|cellular response to hormone stimulus|
|detection of stimulus|
|regulation of protein transport|
|G protein-coupled receptor activity|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|cell migration|
|sensory perception|
|positive regulation of transport|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|cellular response to endogenous stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.7|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.8|
|[[:results:exp114|A-196 10μM R03 exp114]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.427|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14559
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OR51E2 Expression in NALM6 Cells: 0.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>