ORAOV1 [The Human Chemical-Genetic Interaction Map Project]

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======= ORAOV1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LTO1
  * **<color #00a2e8>Official Name</color>**: LTO1 maturation factor of ABCE1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=220064|220064]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WV07|Q8WV07]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ORAOV1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ORAOV1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607224|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Yae1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein maturation by [4Fe-4S] cluster transfer|
|protein maturation by iron-sulfur cluster transfer|
|ribosomal large subunit biogenesis|
|telomere maintenance|
|telomere organization|
|translational initiation|
|protein maturation|
|ribosome biogenesis|
|anatomical structure homeostasis|
|translation|
|peptide biosynthetic process|
|cellular component|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|DNA metabolic process|
|molecular function|
|cellular amide metabolic process|
|chromosome organization|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.06|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.04|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.79|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.76|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.73|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.71|
|[[:results:exp539|42°C R08 exp539]]|1.73|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.77|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.8|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.84|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.94|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.13|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.655|
|[[:human genes:r:rnmt|RNMT]]|0.625|
|[[:human genes:g:gfpt1|GFPT1]]|0.607|
|[[:human genes:d:dpagt1|DPAGT1]]|0.603|
|[[:human genes:p:pmm2|PMM2]]|0.581|
|[[:human genes:u:uap1|UAP1]]|0.578|
|[[:human genes:a:atxn10|ATXN10]]|0.576|
|[[:human genes:g:gmppb|GMPPB]]|0.568|
|[[:human genes:a:alg1|ALG1]]|0.557|
|[[:human genes:a:alg2|ALG2]]|0.554|
|[[:human genes:d:dr1|DR1]]|0.551|
|[[:human genes:r:rptor|RPTOR]]|0.531|
|[[:human genes:m:med16|MED16]]|0.529|
|[[:human genes:t:tgs1|TGS1]]|0.529|
|[[:human genes:d:dad1|DAD1]]|0.527|
|[[:human genes:t:ttc4|TTC4]]|0.527|
|[[:human genes:p:pelo|PELO]]|0.526|
|[[:human genes:d:dohh|DOHH]]|0.526|
|[[:human genes:t:triap1|TRIAP1]]|0.513|
|[[:human genes:r:rtcb|RTCB]]|0.506|
|[[:human genes:h:hspd1|HSPD1]]|0.496|
|[[:human genes:a:alg13|ALG13]]|0.493|
|[[:human genes:t:trnt1|TRNT1]]|0.491|
|[[:human genes:h:haus8|HAUS8]]|0.488|
|[[:human genes:u:utp23|UTP23]]|0.482|
|[[:human genes:p:pam16|PAM16]]|0.48|
|[[:human genes:t:tsen54|TSEN54]]|0.48|
|[[:human genes:s:srp68|SRP68]]|0.478|
|[[:human genes:e:exoc4|EXOC4]]|0.478|
|[[:human genes:t:tsen34|TSEN34]]|0.477|
|[[:human genes:u:uxt|UXT]]|0.473|
|[[:human genes:a:alg5|ALG5]]|0.469|
|[[:human genes:m:mtor|MTOR]]|0.467|
|[[:human genes:r:romo1|ROMO1]]|0.466|
|[[:human genes:t:trmt10a|TRMT10A]]|0.466|
|[[:human genes:a:adsl|ADSL]]|0.464|
|[[:human genes:m:mis18a|MIS18A]]|0.458|
|[[:human genes:d:ddost|DDOST]]|0.458|
|[[:human genes:s:srp72|SRP72]]|0.457|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.457|
|[[:human genes:o:oip5|OIP5]]|0.457|
|[[:human genes:c:crcp|CRCP]]|0.456|
|[[:human genes:e:eif4e|EIF4E]]|0.455|
|[[:human genes:r:rpn1|RPN1]]|0.455|
|[[:human genes:t:tbca|TBCA]]|0.454|
|[[:human genes:g:gnb1l|GNB1L]]|0.452|
|[[:human genes:t:thoc6|THOC6]]|0.45|
|[[:human genes:v:vezt|VEZT]]|0.45|
|[[:human genes:u:uba3|UBA3]]|0.444|
|[[:human genes:c:casp9|CASP9]]|0.444|
|[[:human genes:w:wdr59|WDR59]]|0.443|
|[[:human genes:y:yars|YARS]]|0.443|
|[[:human genes:m:med4|MED4]]|0.442|
|[[:human genes:t:tmem41b|TMEM41B]]|0.441|
|[[:human genes:h:hars|HARS]]|0.44|
|[[:human genes:b:bub3|BUB3]]|0.44|
|[[:human genes:h:hccs|HCCS]]|0.44|
|[[:human genes:s:srp14|SRP14]]|0.439|
|[[:human genes:p:ppcs|PPCS]]|0.438|
|[[:human genes:n:nae1|NAE1]]|0.436|
|[[:human genes:m:mars|MARS]]|0.436|
|[[:human genes:t:tti2|TTI2]]|0.436|
|[[:human genes:t:taz|TAZ]]|0.435|
|[[:human genes:p:polr3h|POLR3H]]|0.434|
|[[:human genes:c:ccdc101|CCDC101]]|0.434|
|[[:human genes:e:eny2|ENY2]]|0.434|
|[[:human genes:p:pdap1|PDAP1]]|0.434|
|[[:human genes:w:wdr24|WDR24]]|0.431|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.429|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.428|
|[[:human genes:c:csnk2b|CSNK2B]]|0.425|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.424|
|[[:human genes:r:rpp21|RPP21]]|0.424|
|[[:human genes:d:dpf2|DPF2]]|0.423|
|[[:human genes:w:wdr82|WDR82]]|0.421|
|[[:human genes:f:fnta|FNTA]]|0.42|
|[[:human genes:d:ddx20|DDX20]]|0.417|
|[[:human genes:d:dhps|DHPS]]|0.417|
|[[:human genes:b:bap1|BAP1]]|0.416|
|[[:human genes:e:elp3|ELP3]]|0.415|
|[[:human genes:r:rpia|RPIA]]|0.414|
|[[:human genes:l:lsmd1|LSMD1]]|0.413|
|[[:human genes:n:nars|NARS]]|0.413|
|[[:human genes:m:meaf6|MEAF6]]|0.413|
|[[:human genes:c:chordc1|CHORDC1]]|0.409|
|[[:human genes:m:mbtps2|MBTPS2]]|0.408|
|[[:human genes:z:znf259|ZNF259]]|0.408|
|[[:human genes:e:eif3f|EIF3F]]|0.407|
|[[:human genes:a:atic|ATIC]]|0.407|
|[[:human genes:r:rpe|RPE]]|0.405|
|[[:human genes:p:ppa2|PPA2]]|0.404|
|[[:human genes:p:plaa|PLAA]]|0.404|
|[[:human genes:z:zbtb11|ZBTB11]]|0.403|
|[[:human genes:e:elac2|ELAC2]]|0.403|
|[[:human genes:t:tamm41|TAMM41]]|0.403|
|[[:human genes:z:zrsr2|ZRSR2]]|0.403|
|[[:human genes:e:eno1|ENO1]]|0.402|
|[[:human genes:s:srprb|SRPRB]]|0.402|
|[[:human genes:t:tbp|TBP]]|0.4|
|[[:human genes:g:gtf2h3|GTF2H3]]|0.4|
|[[:human genes:t:timm22|TIMM22]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 726/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|17/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 273
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ORAOV1 Expression in NALM6 Cells: 5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>