OSBPL11 [The Human Chemical-Genetic Interaction Map Project]

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======= OSBPL11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OSBPL11
  * **<color #00a2e8>Official Name</color>**: oxysterol binding protein like 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114885|114885]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXB4|Q9BXB4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OSBPL11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OSBPL11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606739|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25- hydroxycholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:23028956}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|Oxysterol BP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of sequestering of triglyceride|
|regulation of sequestering of triglyceride|
|sterol binding|
|sterol transporter activity|
|positive regulation of lipid storage|
|regulation of lipid storage|
|sterol transport|
|positive regulation of lipid localization|
|fat cell differentiation|
|late endosome membrane|
|organic hydroxy compound transport|
|regulation of lipid localization|
|lipid binding|
|lipid transport|
|lipid localization|
|intracellular membrane-bounded organelle|
|Golgi apparatus|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-3.62|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-3.07|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.69|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.66|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.08|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.07|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.85|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.83|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.77|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.77|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.74|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.72|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.71|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.7|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.81|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.94|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|5.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:osbpl9|OSBPL9]]|0.467|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16115
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OSBPL11 Expression in NALM6 Cells: 5.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>