OSBPL5 [The Human Chemical-Genetic Interaction Map Project]

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======= OSBPL5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OSBPL5
  * **<color #00a2e8>Official Name</color>**: oxysterol binding protein like 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114879|114879]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0X9|Q9H0X9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OSBPL5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OSBPL5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606733|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|Oxysterol BP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylserine transfer activity|
|oxysterol binding|
|endoplasmic reticulum-plasma membrane contact site|
|sterol binding|
|sterol transporter activity|
|phospholipid transporter activity|
|phosphatidylserine acyl-chain remodeling|
|phosphatidylinositol-4-phosphate binding|
|phosphatidylserine metabolic process|
|cholesterol binding|
|cholesterol transport|
|phosphatidylserine binding|
|Golgi to plasma membrane transport|
|sterol transport|
|phospholipid transport|
|vesicle-mediated transport to the plasma membrane|
|post-Golgi vesicle-mediated transport|
|cholesterol metabolic process|
|organophosphate ester transport|
|secondary alcohol metabolic process|
|sterol metabolic process|
|organic hydroxy compound transport|
|lipid binding|
|cellular modified amino acid metabolic process|
|steroid metabolic process|
|lipid transport|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|lipid localization|
|Golgi vesicle transport|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic hydroxy compound metabolic process|
|organic anion transport|
|anion transport|
|intracellular membrane-bounded organelle|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|lipid metabolic process|
|ion transport|
|small molecule metabolic process|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.9|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.7|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7637
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OSBPL5 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>