OSTN [The Human Chemical-Genetic Interaction Map Project]

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======= OSTN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OSTN
  * **<color #00a2e8>Official Name</color>**: osteocrin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=344901|344901]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61366|P61366]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OSTN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OSTN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity). {ECO:0000250|UniProtKB:P61364, ECO:0000269|PubMed:27830782}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Musclin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of dendrite extension|
|negative regulation of glucose import|
|negative regulation of glucose transmembrane transport|
|regulation of dendrite extension|
|endochondral bone growth|
|negative regulation of osteoblast differentiation|
|bone growth|
|regulation of glucose import|
|regulation of glucose transmembrane transport|
|negative regulation of ossification|
|organ growth|
|hormone activity|
|negative regulation of developmental growth|
|regulation of osteoblast differentiation|
|negative regulation of transmembrane transport|
|negative regulation of neuron projection development|
|hormone-mediated signaling pathway|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of ossification|
|negative regulation of neuron differentiation|
|negative regulation of growth|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|regulation of developmental growth|
|negative regulation of cell development|
|developmental growth|
|growth|
|regulation of cell growth|
|negative regulation of transport|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of transmembrane transport|
|cellular response to hormone stimulus|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|response to hormone|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of anatomical structure morphogenesis|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|generation of neurons|
|extracellular space|
|neurogenesis|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14509
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OSTN Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>