OTOP1 [The Human Chemical-Genetic Interaction Map Project]

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======= OTOP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OTOP1
  * **<color #00a2e8>Official Name</color>**: otopetrin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=133060|133060]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7RTM1|Q7RTM1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OTOP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OTOP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607806|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Otopetrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of gravity|
|proton channel activity|
|negative regulation of response to interferon-gamma|
|negative regulation of interferon-gamma-mediated signaling pathway|
|response to gravity|
|regulation of response to interferon-gamma|
|regulation of interferon-gamma-mediated signaling pathway|
|negative regulation of innate immune response|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|biomineralization|
|negative regulation of response to biotic stimulus|
|biomineral tissue development|
|inner ear morphogenesis|
|ear morphogenesis|
|detection of external stimulus|
|detection of abiotic stimulus|
|proton transmembrane transport|
|negative regulation of immune response|
|cellular response to insulin stimulus|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|inner ear development|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|ear development|
|response to insulin|
|sensory organ morphogenesis|
|cellular response to peptide hormone stimulus|
|embryonic organ morphogenesis|
|cellular response to peptide|
|negative regulation of response to external stimulus|
|response to peptide hormone|
|monovalent inorganic cation transport|
|embryonic organ development|
|negative regulation of immune system process|
|regulation of innate immune response|
|response to peptide|
|regulation of response to biotic stimulus|
|sensory organ development|
|inorganic cation transmembrane transport|
|embryonic morphogenesis|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|detection of stimulus|
|regulation of defense response|
|regulation of multi-organism process|
|cation transport|
|response to hormone|
|ion transmembrane transport|
|animal organ morphogenesis|
|embryo development|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|regulation of response to external stimulus|
|regulation of immune response|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|regulation of immune system process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 33/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|2/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|5/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4337
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OTOP1 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>