OXER1 [The Human Chemical-Genetic Interaction Map Project]

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======= OXER1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OXER1
  * **<color #00a2e8>Official Name</color>**: oxoeicosanoid receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=165140|165140]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDS5|Q8TDS5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OXER1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OXER1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620064|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins. {ECO:0000269|PubMed:12065583, ECO:0000269|PubMed:12606753}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|
|5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|
|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|G protein-coupled receptor activity|
|G protein-coupled receptor signaling pathway|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.93|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.87|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.77|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.77|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.88|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bage|BAGE]]|0.428|
|[[:human genes:b:bage4|BAGE4]]|0.428|
|[[:human genes:b:bage3|BAGE3]]|0.428|
|[[:human genes:b:bage2|BAGE2]]|0.428|
|[[:human genes:b:bage5|BAGE5]]|0.428|
|[[:human genes:k:krt78|KRT78]]|0.423|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2632
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OXER1 Expression in NALM6 Cells: -3.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>