OXSR1 [The Human Chemical-Genetic Interaction Map Project]

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======= OXSR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OXSR1
  * **<color #00a2e8>Official Name</color>**: oxidative stress responsive kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9943|9943]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95747|O95747]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OXSR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OXSR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604046|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. {ECO:0000269|PubMed:14707132, ECO:0000303|PubMed:14707132}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|OSR1 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|osmosensory signaling pathway|
|signal transduction by trans-phosphorylation|
|chemokine (C-X-C motif) ligand 12 signaling pathway|
|chemokine (C-C motif) ligand 21 signaling pathway|
|cellular hypotonic response|
|hypotonic response|
|positive regulation of T cell chemotaxis|
|regulation of T cell chemotaxis|
|negative regulation of potassium ion transmembrane transporter activity|
|positive regulation of lymphocyte chemotaxis|
|negative regulation of potassium ion transmembrane transport|
|regulation of lymphocyte chemotaxis|
|positive regulation of T cell migration|
|negative regulation of potassium ion transport|
|cellular response to osmotic stress|
|positive regulation of lymphocyte migration|
|regulation of T cell migration|
|regulation of potassium ion transmembrane transporter activity|
|regulation of lymphocyte migration|
|negative regulation of ion transmembrane transporter activity|
|response to osmotic stress|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|chemokine-mediated signaling pathway|
|peptidyl-threonine phosphorylation|
|negative regulation of cation transmembrane transport|
|positive regulation of leukocyte chemotaxis|
|response to chemokine|
|cellular response to chemokine|
|peptidyl-threonine modification|
|regulation of potassium ion transport|
|negative regulation of ion transmembrane transport|
|regulation of leukocyte chemotaxis|
|negative regulation of transmembrane transport|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|stress-activated protein kinase signaling cascade|
|negative regulation of ion transport|
|protein autophosphorylation|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|magnesium ion binding|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|activation of protein kinase activity|
|regulation of cation transmembrane transport|
|protein serine/threonine kinase activity|
|regulation of metal ion transport|
|response to oxidative stress|
|signal transduction by protein phosphorylation|
|protein kinase binding|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of ion transport|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|regulation of cell motility|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|identical protein binding|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.89|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16553
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OXSR1 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>