P2RX3 [The Human Chemical-Genetic Interaction Map Project]

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======= P2RX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: P2RX3
  * **<color #00a2e8>Official Name</color>**: purinergic receptor P2X 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5024|5024]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56373|P56373]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=P2RX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20P2RX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600843|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for ATP that acts as a ligand-gated ion channel.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P2X receptor|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|behavioral response to formalin induced pain|
|behavioral response to chemical pain|
|ATP-gated ion channel activity|
|urinary tract smooth muscle contraction|
|purinergic nucleotide receptor activity|
|urinary bladder smooth muscle contraction|
|positive regulation of sensory perception of pain|
|extracellularly ATP-gated cation channel activity|
|peristalsis|
|behavioral response to pain|
|integral component of nuclear inner membrane|
|chemosensory behavior|
|phasic smooth muscle contraction|
|cellular response to ATP|
|purinergic nucleotide receptor signaling pathway|
|purinergic receptor signaling pathway|
|neuronal action potential|
|response to pain|
|response to ATP|
|protein homotrimerization|
|neuromuscular synaptic transmission|
|hippocampal mossy fiber to CA3 synapse|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|positive regulation of calcium-mediated signaling|
|terminal bouton|
|response to cold|
|smooth muscle contraction|
|positive regulation of calcium ion transport into cytosol|
|protein trimerization|
|transmission of nerve impulse|
|integral component of presynaptic membrane|
|rough endoplasmic reticulum|
|positive regulation of nervous system process|
|excitatory postsynaptic potential|
|sensory perception of taste|
|chemical synaptic transmission, postsynaptic|
|cellular response to nutrient|
|multicellular organismal response to stress|
|Schaffer collateral - CA1 synapse|
|action potential|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|regulation of postsynaptic membrane potential|
|response to heat|
|positive regulation of calcium ion transport|
|multicellular organismal signaling|
|response to organophosphorus|
|regulation of nervous system process|
|dendritic spine|
|response to purine-containing compound|
|response to carbohydrate|
|response to temperature stimulus|
|regulation of synaptic plasticity|
|receptor complex|
|response to mechanical stimulus|
|response to nutrient|
|membrane raft|
|cellular response to nutrient levels|
|regulation of calcium ion transport|
|muscle contraction|
|cellular response to extracellular stimulus|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|blood coagulation|
|coagulation|
|hemostasis|
|muscle system process|
|regulation of cytosolic calcium ion concentration|
|cellular response to external stimulus|
|protein homooligomerization|
|response to hypoxia|
|response to decreased oxygen levels|
|neuronal cell body|
|response to oxygen levels|
|regulation of metal ion transport|
|monovalent inorganic cation transport|
|cellular response to drug|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|response to nutrient levels|
|protein complex oligomerization|
|response to extracellular stimulus|
|sensory perception of chemical stimulus|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|response to wounding|
|behavior|
|regulation of system process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|ion transmembrane transport|
|sensory perception|
|Golgi apparatus|
|positive regulation of transport|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8258
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='P2RX3 Expression in NALM6 Cells: -0.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>