PABPC1L [The Human Chemical-Genetic Interaction Map Project]

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======= PABPC1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PABPC1L
  * **<color #00a2e8>Official Name</color>**: poly(A) binding protein cytoplasmic 1 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80336|80336]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4VXU2|Q4VXU2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PABPC1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PABPC1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621055|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PABP|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromatin-mediated maintenance of transcription|
|oocyte maturation|
|poly(A) binding|
|nucleus localization|
|mRNA polyadenylation|
|poly(U) RNA binding|
|RNA polyadenylation|
|oocyte development|
|oocyte differentiation|
|positive regulation of gene expression, epigenetic|
|cytoplasmic stress granule|
|chromatin organization involved in regulation of transcription|
|mRNA 3-UTR binding|
|oogenesis|
|mRNA 3-end processing|
|female gamete generation|
|RNA 3-end processing|
|anatomical structure maturation|
|ribonucleoprotein complex|
|cell maturation|
|chromatin remodeling|
|regulation of gene expression, epigenetic|
|developmental maturation|
|germ cell development|
|cellular process involved in reproduction in multicellular organism|
|mRNA processing|
|organelle localization|
|developmental process involved in reproduction|
|gamete generation|
|mRNA metabolic process|
|chromatin organization|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|RNA processing|
|multi-organism reproductive process|
|chromosome organization|
|RNA binding|
|reproductive process|
|reproduction|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp132|Metformin 40μM R03 exp132]]|-2.27|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-2.01|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.94|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.91|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.87|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.87|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.81|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.76|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.7|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12325
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PABPC1L Expression in NALM6 Cells: 5.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>