PACSIN1 [The Human Chemical-Genetic Interaction Map Project]

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======= PACSIN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PACSIN1
  * **<color #00a2e8>Official Name</color>**: protein kinase C and casein kinase substrate in neurons 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29993|29993]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BY11|Q9BY11]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PACSIN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PACSIN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606512|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|FCH|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|presynaptic endocytic zone|
|photoreceptor ribbon synapse|
|COPI-coated vesicle|
|plasma membrane tubulation|
|presynaptic endocytosis|
|negative regulation of endocytosis|
|synaptic vesicle endocytosis|
|axon terminus|
|synaptic vesicle recycling|
|positive regulation of dendrite development|
|cytoskeletal protein binding|
|plasma membrane organization|
|ruffle membrane|
|phospholipid binding|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|cytoplasmic vesicle membrane|
|regulation of dendrite development|
|protein localization to plasma membrane|
|regulation of endocytosis|
|protein localization to cell periphery|
|actin filament organization|
|synapse|
|positive regulation of neuron projection development|
|cytoskeleton|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|endomembrane system organization|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|regulation of vesicle-mediated transport|
|endocytosis|
|actin filament-based process|
|regulation of neuron differentiation|
|neuron projection development|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|membrane organization|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|neuron differentiation|
|identical protein binding|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|generation of neurons|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.91|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.73|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.72|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.72|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.76|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8649
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PACSIN1 Expression in NALM6 Cells: -1.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>