PACSIN2 [The Human Chemical-Genetic Interaction Map Project]

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======= PACSIN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PACSIN2
  * **<color #00a2e8>Official Name</color>**: protein kinase C and casein kinase substrate in neurons 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11252|11252]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNF0|Q9UNF0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PACSIN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PACSIN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604960|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. {ECO:0000269|PubMed:21610094, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|FCH|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|caveola assembly|
|caveolin-mediated endocytosis|
|plasma membrane raft assembly|
|plasma membrane raft organization|
|membrane raft assembly|
|protein localization to endosome|
|plasma membrane tubulation|
|phosphatidic acid binding|
|membrane raft organization|
|membrane assembly|
|membrane biogenesis|
|transporter activity|
|negative regulation of endocytosis|
|extrinsic component of membrane|
|caveola|
|cytoskeletal protein binding|
|recycling endosome membrane|
|plasma membrane organization|
|ruffle membrane|
|phospholipid binding|
|cytoplasmic vesicle membrane|
|cell-cell junction|
|regulation of endocytosis|
|early endosome|
|cadherin binding|
|glutamatergic synapse|
|cytoskeleton|
|nuclear speck|
|focal adhesion|
|endomembrane system organization|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of transport|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|cell part morphogenesis|
|regulation of vesicle-mediated transport|
|endocytosis|
|actin filament-based process|
|import into cell|
|intracellular membrane-bounded organelle|
|negative regulation of cellular component organization|
|cell morphogenesis|
|protein localization to organelle|
|cellular component morphogenesis|
|membrane organization|
|identical protein binding|
|cytoskeleton organization|
|cell projection organization|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.08|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.93|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.8|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.85|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9487
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PACSIN2 Expression in NALM6 Cells: 6.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>