PADI4 [The Human Chemical-Genetic Interaction Map Project]

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======= PADI4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PADI4
  * **<color #00a2e8>Official Name</color>**: peptidyl arginine deiminase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23569|23569]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UM07|Q9UM07]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PADI4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PADI4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605347|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg- 54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1. {ECO:0000269|PubMed:15339660, ECO:0000269|PubMed:15345777, ECO:0000269|PubMed:15731352, ECO:0000269|PubMed:16567635, ECO:0000269|PubMed:18209087, ECO:0000269|PubMed:21245532}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAD N|
|PAD|
|PAD M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|arginine deiminase pathway|
|arginine deiminase activity|
|histone H3-R26 citrullination|
|protein-arginine deiminase activity|
|histone citrullination|
|protein citrullination|
|arginine binding|
|arginine catabolic process|
|arginine metabolic process|
|glutamine family amino acid catabolic process|
|peptidyl-arginine modification|
|glutamine family amino acid metabolic process|
|alpha-amino acid catabolic process|
|nucleosome assembly|
|cellular amino acid catabolic process|
|chromatin assembly|
|stem cell population maintenance|
|maintenance of cell number|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|DNA packaging|
|protein-DNA complex assembly|
|alpha-amino acid metabolic process|
|protein-DNA complex subunit organization|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|DNA conformation change|
|cellular amino acid metabolic process|
|histone modification|
|covalent chromatin modification|
|small molecule catabolic process|
|protein-containing complex|
|chromatin organization|
|calcium ion binding|
|innate immune response|
|cellular protein-containing complex assembly|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|carboxylic acid metabolic process|
|defense response to other organism|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|protein-containing complex assembly|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.7|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.78|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.434|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5104
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PADI4 Expression in NALM6 Cells: 0.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>