PAEP [The Human Chemical-Genetic Interaction Map Project]

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======= PAEP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAEP
  * **<color #00a2e8>Official Name</color>**: progestagen associated endometrial protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5047|5047]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09466|P09466]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAEP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAEP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173310|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa- zona pellucida binding and significantly suppresses progesterone- induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155). {ECO:0000269|PubMed:12672671, ECO:0000269|PubMed:15883155, ECO:0000269|PubMed:17192260, ECO:0000269|PubMed:7531163, ECO:0000269|PubMed:9918684}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipocalin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of sperm capacitation|
|regulation of sperm capacitation|
|regulation of binding of sperm to zona pellucida|
|positive regulation of interleukin-13 secretion|
|negative regulation of cell maturation|
|regulation of interleukin-13 secretion|
|small molecule binding|
|positive regulation of granulocyte macrophage colony-stimulating factor production|
|positive regulation of interleukin-13 production|
|regulation of granulocyte macrophage colony-stimulating factor production|
|regulation of interleukin-13 production|
|regulation of cell maturation|
|regulation of fertilization|
|positive regulation of interleukin-6 secretion|
|negative regulation of reproductive process|
|positive regulation of interleukin-6 production|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|regulation of reproductive process|
|regulation of cytokine secretion|
|negative regulation of multi-organism process|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|negative regulation of cell development|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of cytokine production|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of multi-organism process|
|regulation of secretion|
|apoptotic process|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of transport|
|regulation of protein localization|
|programmed cell death|
|cell death|
|negative regulation of multicellular organismal process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5841
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAEP Expression in NALM6 Cells: -0.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>