PAN2 [The Human Chemical-Genetic Interaction Map Project]

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======= PAN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAN2
  * **<color #00a2e8>Official Name</color>**: poly(A) specific ribonuclease subunit PAN2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9924|9924]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q504Q3|Q504Q3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617447|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618, ECO:0000269|PubMed:23398456}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNase T|
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PAN complex|
|positive regulation of cytoplasmic mRNA processing body assembly|
|regulation of cytoplasmic mRNA processing body assembly|
|poly(A)-specific ribonuclease activity|
|nuclear-transcribed mRNA poly(A) tail shortening|
|3-5-exoribonuclease activity|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|positive regulation of organelle assembly|
|P-body|
|RNA phosphodiester bond hydrolysis|
|nucleic acid binding|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|regulation of organelle assembly|
|RNA catabolic process|
|positive regulation of protein complex assembly|
|nucleic acid phosphodiester bond hydrolysis|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|regulation of protein complex assembly|
|mRNA processing|
|organic cyclic compound catabolic process|
|positive regulation of cellular component biogenesis|
|positive regulation of organelle organization|
|mRNA metabolic process|
|RNA processing|
|cellular macromolecule catabolic process|
|regulation of cellular component biogenesis|
|macromolecule catabolic process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.57|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.49|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.28|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.28|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.24|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.07|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.03|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.93|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.89|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.85|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.83|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.82|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.81|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.8|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.72|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.72|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.9|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.99|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.01|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.09|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.1|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.25|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pan3|PAN3]]|0.672|
|[[:human genes:p:psmd11|PSMD11]]|0.564|
|[[:human genes:s:smg7|SMG7]]|0.564|
|[[:human genes:s:supt6h|SUPT6H]]|0.555|
|[[:human genes:c:chd4|CHD4]]|0.537|
|[[:human genes:v:vasn|VASN]]|0.536|
|[[:human genes:c:cdca3|CDCA3]]|0.522|
|[[:human genes:s:smg1|SMG1]]|0.507|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.507|
|[[:human genes:s:slc6a17|SLC6A17]]|0.506|
|[[:human genes:z:zfand5|ZFAND5]]|0.503|
|[[:human genes:p:psmc6|PSMC6]]|0.498|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.497|
|[[:human genes:t:tceb3c|TCEB3C]]|0.496|
|[[:human genes:s:sfpq|SFPQ]]|0.492|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.492|
|[[:human genes:u:upf1|UPF1]]|0.489|
|[[:human genes:l:lrr1|LRR1]]|0.489|
|[[:human genes:o:orc1|ORC1]]|0.485|
|[[:human genes:p:psmc2|PSMC2]]|0.484|
|[[:human genes:c:c14orf93|C14orf93]]|0.484|
|[[:human genes:p:psmd3|PSMD3]]|0.483|
|[[:human genes:d:disp2|DISP2]]|0.482|
|[[:human genes:a:aatf|AATF]]|0.478|
|[[:human genes:c:cbwd3|CBWD3]]|0.478|
|[[:human genes:p:psmd14|PSMD14]]|0.475|
|[[:human genes:a:aqr|AQR]]|0.474|
|[[:human genes:p:psmc1|PSMC1]]|0.471|
|[[:human genes:p:psma6|PSMA6]]|0.471|
|[[:human genes:i:ik|IK]]|0.468|
|[[:human genes:n:npipb5|NPIPB5]]|0.467|
|[[:human genes:m:mt1e|MT1E]]|0.467|
|[[:human genes:p:polr1a|POLR1A]]|0.467|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.467|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.466|
|[[:human genes:g:gata3|GATA3]]|0.466|
|[[:human genes:d:ddtl|DDTL]]|0.463|
|[[:human genes:m:med14|MED14]]|0.461|
|[[:human genes:p:psmb4|PSMB4]]|0.46|
|[[:human genes:c:ccna2|CCNA2]]|0.46|
|[[:human genes:a:atxn1|ATXN1]]|0.46|
|[[:human genes:r:rad21|RAD21]]|0.46|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.456|
|[[:human genes:h:hap1|HAP1]]|0.456|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.455|
|[[:human genes:r:rplp1|RPLP1]]|0.455|
|[[:human genes:g:golga8o|GOLGA8O]]|0.454|
|[[:human genes:p:pola1|POLA1]]|0.453|
|[[:human genes:c:copb1|COPB1]]|0.453|
|[[:human genes:s:slc38a7|SLC38A7]]|0.453|
|[[:human genes:o:orc6|ORC6]]|0.452|
|[[:human genes:o:ogfr|OGFR]]|0.452|
|[[:human genes:p:psmb2|PSMB2]]|0.452|
|[[:human genes:a:atp13a1|ATP13A1]]|0.449|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.448|
|[[:human genes:h:hivep3|HIVEP3]]|0.447|
|[[:human genes:m:med17|MED17]]|0.447|
|[[:human genes:n:nup205|NUP205]]|0.446|
|[[:human genes:k:kctd17|KCTD17]]|0.446|
|[[:human genes:d:dtl|DTL]]|0.445|
|[[:human genes:c:col2a1|COL2A1]]|0.444|
|[[:human genes:r:rps19|RPS19]]|0.443|
|[[:human genes:p:psmd7|PSMD7]]|0.443|
|[[:human genes:h:hist2h3d|HIST2H3D]]|0.443|
|[[:human genes:p:polr2d|POLR2D]]|0.443|
|[[:human genes:c:copb2|COPB2]]|0.442|
|[[:human genes:p:paf1|PAF1]]|0.441|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.44|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.439|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.439|
|[[:human genes:g:gid4|GID4]]|0.438|
|[[:human genes:w:wdr43|WDR43]]|0.438|
|[[:human genes:f:fcn2|FCN2]]|0.438|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.437|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.437|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.437|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.437|
|[[:human genes:u:uqcrh|UQCRH]]|0.437|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.437|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.437|
|[[:human genes:e:eif4a3|EIF4A3]]|0.436|
|[[:human genes:c:cdt1|CDT1]]|0.435|
|[[:human genes:n:nol10|NOL10]]|0.434|
|[[:human genes:p:psmd1|PSMD1]]|0.434|
|[[:human genes:a:arcn1|ARCN1]]|0.434|
|[[:human genes:r:rrp7a|RRP7A]]|0.434|
|[[:human genes:t:tsg101|TSG101]]|0.433|
|[[:human genes:p:psmb1|PSMB1]]|0.432|
|[[:human genes:s:sult1a3|SULT1A3]]|0.432|
|[[:human genes:s:sult1a4|SULT1A4]]|0.431|
|[[:human genes:c:copa|COPA]]|0.431|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.431|
|[[:human genes:t:ticrr|TICRR]]|0.431|
|[[:human genes:a:aaas|AAAS]]|0.43|
|[[:human genes:m:mbtd1|MBTD1]]|0.428|
|[[:human genes:n:nop16|NOP16]]|0.428|
|[[:human genes:k:kpnb1|KPNB1]]|0.428|
|[[:human genes:p:pigs|PIGS]]|0.428|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.427|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.426|
|[[:human genes:r:rfc1|RFC1]]|0.426|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.426|
|[[:human genes:z:znf830|ZNF830]]|0.425|
|[[:human genes:a:ankle2|ANKLE2]]|0.425|
|[[:human genes:p:pcf11|PCF11]]|0.423|
|[[:human genes:p:pola2|POLA2]]|0.423|
|[[:human genes:p:psmc4|PSMC4]]|0.422|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.422|
|[[:human genes:f:fbl|FBL]]|0.421|
|[[:human genes:s:sf3b3|SF3B3]]|0.421|
|[[:human genes:s:ssh2|SSH2]]|0.421|
|[[:human genes:m:med12|MED12]]|0.42|
|[[:human genes:s:snrpa1|SNRPA1]]|0.419|
|[[:human genes:s:scaf1|SCAF1]]|0.419|
|[[:human genes:s:smg5|SMG5]]|0.418|
|[[:human genes:n:nup153|NUP153]]|0.418|
|[[:human genes:c:clptm1|CLPTM1]]|0.417|
|[[:human genes:s:s1pr4|S1PR4]]|0.416|
|[[:human genes:n:nupl1|NUPL1]]|0.416|
|[[:human genes:t:twistnb|TWISTNB]]|0.415|
|[[:human genes:w:wdr75|WDR75]]|0.415|
|[[:human genes:a:aamp|AAMP]]|0.414|
|[[:human genes:m:mfsd12|MFSD12]]|0.414|
|[[:human genes:p:pwp2|PWP2]]|0.414|
|[[:human genes:r:rps7|RPS7]]|0.412|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.412|
|[[:human genes:w:wdr87|WDR87]]|0.412|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.412|
|[[:human genes:c:cope|COPE]]|0.411|
|[[:human genes:c:cdc73|CDC73]]|0.411|
|[[:human genes:p:polr2a|POLR2A]]|0.41|
|[[:human genes:c:copg1|COPG1]]|0.409|
|[[:human genes:u:ubap2l|UBAP2L]]|0.409|
|[[:human genes:c:chchd3|CHCHD3]]|0.409|
|[[:human genes:c:chmp2a|CHMP2A]]|0.408|
|[[:human genes:p:pole|POLE]]|0.408|
|[[:human genes:r:rps5|RPS5]]|0.408|
|[[:human genes:r:ranbp2|RANBP2]]|0.408|
|[[:human genes:p:pbxip1|PBXIP1]]|0.408|
|[[:human genes:c:cbwd5|CBWD5]]|0.407|
|[[:human genes:z:znf106|ZNF106]]|0.407|
|[[:human genes:l:lad1|LAD1]]|0.407|
|[[:human genes:r:rps9|RPS9]]|0.406|
|[[:human genes:m:med29|MED29]]|0.406|
|[[:human genes:t:terf2|TERF2]]|0.405|
|[[:human genes:a:adrm1|ADRM1]]|0.404|
|[[:human genes:t:tuba8|TUBA8]]|0.404|
|[[:human genes:d:ddx21|DDX21]]|0.404|
|[[:human genes:r:rpl3l|RPL3L]]|0.404|
|[[:human genes:c:ccdc94|CCDC94]]|0.403|
|[[:human genes:r:rps2|RPS2]]|0.401|
|[[:human genes:p:psmc3|PSMC3]]|0.4|
|[[:human genes:s:supt5h|SUPT5H]]|0.4|
|[[:human genes:c:cwc22|CWC22]]|0.4|
|[[:human genes:k:krt78|KRT78]]|0.4|
|[[:human genes:a:abt1|ABT1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1571
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAN2 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>