PANX1 [The Human Chemical-Genetic Interaction Map Project]

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======= PANX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PANX1
  * **<color #00a2e8>Official Name</color>**: pannexin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=24145|24145]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96RD7|Q96RD7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PANX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PANX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608420|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. {ECO:0000269|PubMed:16908669, ECO:0000269|PubMed:20829356}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Innexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leak channel activity|
|positive regulation of interleukin-1 alpha secretion|
|wide pore channel activity|
|regulation of interleukin-1 alpha secretion|
|positive regulation of interleukin-1 alpha production|
|regulation of interleukin-1 alpha production|
|gap junction hemi-channel activity|
|bleb|
|protein hexamerization|
|gap junction|
|response to ATP|
|positive regulation of interleukin-1 beta secretion|
|positive regulation of interleukin-1 secretion|
|regulation of interleukin-1 beta secretion|
|response to ischemia|
|positive regulation of interleukin-1 beta production|
|calcium channel activity|
|regulation of interleukin-1 secretion|
|positive regulation of interleukin-1 production|
|scaffold protein binding|
|regulation of interleukin-1 beta production|
|regulation of interleukin-1 production|
|protease binding|
|ion channel binding|
|response to organophosphorus|
|positive regulation of cytokine secretion|
|response to purine-containing compound|
|calcium ion transmembrane transport|
|actin filament binding|
|regulation of cytokine secretion|
|response to nutrient|
|calcium ion transport|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|divalent metal ion transport|
|divalent inorganic cation transport|
|signaling receptor binding|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|protein heterodimerization activity|
|regulation of peptide secretion|
|response to nutrient levels|
|protein complex oligomerization|
|response to extracellular stimulus|
|inorganic cation transmembrane transport|
|protein-containing complex|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|cation transport|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|positive regulation of transport|
|response to organonitrogen compound|
|endoplasmic reticulum|
|response to drug|
|regulation of protein localization|
|response to nitrogen compound|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|positive regulation of multicellular organismal process|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.82|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.04|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.92|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.82|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.83|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11193
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PANX1 Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>