PAPOLB [The Human Chemical-Genetic Interaction Map Project]

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======= PAPOLB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAPOLB
  * **<color #00a2e8>Official Name</color>**: poly(A) polymerase beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56903|56903]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRJ5|Q9NRJ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAPOLB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAPOLB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607436|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAP RNA-bind|
|PAP central|
|NTP transf 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polynucleotide adenylyltransferase activity|
|mRNA polyadenylation|
|RNA polyadenylation|
|mRNA 3-end processing|
|RNA 3-end processing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|ATP binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.74|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.75|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.08|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17624
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAPOLB Expression in NALM6 Cells: 1.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>