PARD3B [The Human Chemical-Genetic Interaction Map Project]

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======= PARD3B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PARD3B
  * **<color #00a2e8>Official Name</color>**: par-3 family cell polarity regulator beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=117583|117583]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TEW8|Q8TEW8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PARD3B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PARD3B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619353|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
|DUF3534|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of centrosome localization|
|apical junction complex|
|centrosome localization|
|microtubule organizing center localization|
|establishment or maintenance of epithelial cell apical/basal polarity|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|adherens junction|
|endomembrane system|
|phosphatidylinositol binding|
|cell-cell adherens junction|
|establishment of cell polarity|
|bicellular tight junction|
|cell cortex|
|establishment or maintenance of cell polarity|
|nuclear body|
|apical plasma membrane|
|establishment of organelle localization|
|microtubule cytoskeleton organization|
|cell division|
|cell junction|
|organelle localization|
|protein-containing complex|
|microtubule-based process|
|cell adhesion|
|biological adhesion|
|cytoskeleton organization|
|cell cycle|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.24|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.96|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.7|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.74|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17268
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PARD3B Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>