PARD6A [The Human Chemical-Genetic Interaction Map Project]

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======= PARD6A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PARD6A
  * **<color #00a2e8>Official Name</color>**: par-6 family cell polarity regulator alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50855|50855]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPB6|Q9NPB6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PARD6A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PARD6A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607484|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). {ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:20719959}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
|PB1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein localization to centrosome|
|regulation of protein localization to centrosome|
|cell-cell junction maintenance|
|cell junction maintenance|
|GTP-dependent protein binding|
|centriolar satellite|
|Rho GTPase binding|
|bicellular tight junction assembly|
|tight junction assembly|
|tight junction organization|
|apical junction assembly|
|cellular component maintenance|
|protein kinase C binding|
|centrosome cycle|
|ruffle|
|microtubule organizing center organization|
|Wnt signaling pathway, planar cell polarity pathway|
|transforming growth factor beta receptor signaling pathway|
|cell-cell junction assembly|
|regulation of establishment of planar polarity|
|bicellular tight junction|
|non-canonical Wnt signaling pathway|
|cell cortex|
|cell-cell junction organization|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|cell junction assembly|
|regulation of morphogenesis of an epithelium|
|establishment or maintenance of cell polarity|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell junction organization|
|regulation of animal organ morphogenesis|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|apical plasma membrane|
|positive regulation of cellular protein localization|
|transcription factor binding|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|positive regulation of secretion by cell|
|negative regulation of protein phosphorylation|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of secretion|
|negative regulation of phosphorylation|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|regulation of peptide secretion|
|cellular response to growth factor stimulus|
|response to growth factor|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|microtubule-based process|
|viral process|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|regulation of cellular localization|
|positive regulation of transport|
|cell cycle process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|cell cycle|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of phosphorylation|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14194
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PARD6A Expression in NALM6 Cells: 2.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>