PARD6B [The Human Chemical-Genetic Interaction Map Project]

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======= PARD6B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PARD6B
  * **<color #00a2e8>Official Name</color>**: par-6 family cell polarity regulator beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84612|84612]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYG5|Q9BYG5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PARD6B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PARD6B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608975|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PB1|
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rho GTPase binding|
|bicellular tight junction assembly|
|tight junction assembly|
|tight junction organization|
|apical junction assembly|
|protein kinase C binding|
|centrosome cycle|
|microtubule organizing center organization|
|cell-cell junction assembly|
|bicellular tight junction|
|cell cortex|
|cell-cell junction organization|
|cell junction assembly|
|establishment or maintenance of cell polarity|
|cell junction organization|
|apical plasma membrane|
|axonogenesis|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell division|
|cell part morphogenesis|
|cell morphogenesis involved in differentiation|
|protein-containing complex|
|neuron projection development|
|microtubule-based process|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of locomotion|
|regulation of cellular component movement|
|cell cycle process|
|neuron differentiation|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cell cycle|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 27/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|5/21|
|liver|3/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15872
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PARD6B Expression in NALM6 Cells: 3.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>