PARK7 [The Human Chemical-Genetic Interaction Map Project]

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======= PARK7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PARK7
  * **<color #00a2e8>Official Name</color>**: Parkinsonism associated deglycase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11315|11315]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99497|Q99497]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PARK7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PARK7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602533|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:28013050, PubMed:26995087). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity (PubMed:22523093). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785, PubMed:26995087). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal- binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). {ECO:0000250|UniProtKB:Q99LX0, ECO:0000269|PubMed:11477070, ECO:0000269|PubMed:12612053, ECO:0000269|PubMed:12855764, ECO:0000269|PubMed:12939276, ECO:0000269|PubMed:14749723, ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:15502874, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:17015834, ECO:0000269|PubMed:18626009, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20186336, ECO:0000269|PubMed:20304780, ECO:0000269|PubMed:21097510, ECO:0000269|PubMed:22523093, ECO:0000269|PubMed:23792957, ECO:0000269|PubMed:23847046, ECO:0000269|PubMed:25416785, ECO:0000269|PubMed:26995087, ECO:0000269|PubMed:28013050, ECO:0000269|PubMed:28596309, ECO:0000269|PubMed:9070310}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DJ-1 PfpI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of L-dopa biosynthetic process|
|protein deglycation, glyoxal removal|
|positive regulation of L-dopa decarboxylase activity|
|positive regulation of pyrroline-5-carboxylate reductase activity|
|glyoxal metabolic process|
|regulation of death-inducing signaling complex assembly|
|glycolate biosynthetic process|
|protein deglycase activity|
|protein deglycation|
|guanine deglycation, methylglyoxal removal|
|peptidyl-lysine deglycation|
|glutathione deglycation|
|positive regulation of oxidative phosphorylation uncoupler activity|
|guanine deglycation, glyoxal removal|
|cellular detoxification of methylglyoxal|
|guanine deglycation|
|negative regulation of TRAIL-activated apoptotic signaling pathway|
|tyrosine 3-monooxygenase activator activity|
|mercury ion binding|
|peptidyl-cysteine deglycation|
|negative regulation of death-inducing signaling complex assembly|
|regulation of TRAIL receptor biosynthetic process|
|peptidyl-arginine deglycation|
|regulation of L-dopa biosynthetic process|
|enzyme active site formation via L-cysteine sulfinic acid|
|positive regulation of tyrosine 3-monooxygenase activity|
|positive regulation of cellular amino acid biosynthetic process|
|regulation of pyrroline-5-carboxylate reductase activity|
|regulation of tyrosine 3-monooxygenase activity|
|regulation of L-dopa decarboxylase activity|
|protein deglycation, methylglyoxal removal|
|L-dopa decarboxylase activator activity|
|cellular response to glyoxal|
|negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway|
|detoxification of mercury ion|
|regulation of dopamine biosynthetic process|
|regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of protein K48-linked deubiquitination|
|positive regulation of dopamine biosynthetic process|
|regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway|
|negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway|
|enzyme active site formation|
|cellular response to methylglyoxal|
|negative regulation of ubiquitin-specific protease activity|
|regulation of cellular amino acid biosynthetic process|
|glycolate metabolic process|
|superoxide dismutase copper chaperone activity|
|positive regulation of removal of superoxide radicals|
|regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|
|negative regulation of protein deubiquitination|
|positive regulation of mitochondrial electron transport, NADH to ubiquinone|
|regulation of protein K48-linked deubiquitination|
|lactate biosynthetic process|
|positive regulation of cellular amino acid metabolic process|
|response to methylglyoxal|
|positive regulation of superoxide dismutase activity|
|peroxiredoxin activity|
|negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|
|catecholamine uptake involved in synaptic transmission|
|regulation of ubiquitin-specific protease activity|
|positive regulation of androgen receptor activity|
|dopamine uptake involved in synaptic transmission|
|regulation of superoxide dismutase activity|
|cupric ion binding|
|primary alcohol biosynthetic process|
|regulation of TRAIL-activated apoptotic signaling pathway|
|peptidyl-cysteine oxidation|
|regulation of oxidative phosphorylation uncoupler activity|
|positive regulation of mitochondrial ATP synthesis coupled electron transport|
|oxidoreductase activity, acting on peroxide as acceptor|
|negative regulation of hydrogen peroxide-mediated programmed cell death|
|negative regulation of hydrogen peroxide-induced neuron death|
|regulation of mitochondrial electron transport, NADH to ubiquinone|
|regulation of hydrogen peroxide-induced neuron death|
|negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|
|small protein activating enzyme binding|
|methylglyoxal metabolic process|
|positive regulation of catecholamine metabolic process|
|positive regulation of dopamine metabolic process|
|ubiquitin-like protein conjugating enzyme binding|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of protein export from nucleus|
|protein repair|
|cuprous ion binding|
|regulation of mitochondrial ATP synthesis coupled electron transport|
|positive regulation of NAD(P)H oxidase activity|
|positive regulation of response to reactive oxygen species|
|dopamine uptake|
|regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|
|catecholamine uptake|
|positive regulation of acute inflammatory response to antigenic stimulus|
|positive regulation of cellular respiration|
|positive regulation of cellular amine metabolic process|
|membrane hyperpolarization|
|regulation of hydrogen peroxide-mediated programmed cell death|
|negative regulation of protein sumoylation|
|cellular response to aldehyde|
|positive regulation of oxidative phosphorylation|
|regulation of removal of superoxide radicals|
|regulation of NAD(P)H oxidase activity|
|response to mercury ion|
|positive regulation of protein homodimerization activity|
|dopamine transport|
|positive regulation of inflammatory response to antigenic stimulus|
|regulation of protein deubiquitination|
|lactate metabolic process|
|protein oxidation|
|regulation of acute inflammatory response to antigenic stimulus|
|core promoter binding|
|catecholamine transport|
|neurotransmitter reuptake|
|positive regulation of oxidative stress-induced cell death|
|stress response to copper ion|
|negative regulation of hydrogen peroxide-induced cell death|
|negative regulation of ubiquitin-protein transferase activity|
|detoxification of copper ion|
|negative regulation of response to reactive oxygen species|
|regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|positive regulation of cellular response to oxidative stress|
|ubiquitin-specific protease binding|
|detoxification of inorganic compound|
|stress response to metal ion|
|synaptic transmission, dopaminergic|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|positive regulation of autophagy of mitochondrion|
|positive regulation of response to oxidative stress|
|negative regulation of cellular response to drug|
|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of oxidative stress-induced neuron death|
|negative regulation of nucleocytoplasmic transport|
|regulation of dopamine metabolic process|
|regulation of catecholamine metabolic process|
|negative regulation of protein acetylation|
|monoamine transport|
|regulation of protein sumoylation|
|maintenance of protein location in nucleus|
|regulation of hydrogen peroxide-induced cell death|
|regulation of protein homodimerization activity|
|regulation of proton transport|
|regulation of receptor biosynthetic process|
|positive regulation of lyase activity|
|regulation of inflammatory response to antigenic stimulus|
|positive regulation of transcription regulatory region DNA binding|
|regulation of oxidative stress-induced neuron death|
|regulation of androgen receptor signaling pathway|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|peptidyl-arginine modification|
|positive regulation of monooxygenase activity|
|negative regulation of reactive oxygen species biosynthetic process|
|negative regulation of response to drug|
|positive regulation of acute inflammatory response|
|neurotransmitter uptake|
|regulation of cellular respiration|
|protein deglycosylation|
|regulation of oxidative phosphorylation|
|activation of protein kinase B activity|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|regulation of superoxide metabolic process|
|regulation of response to reactive oxygen species|
|regulation of cellular response to drug|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|regulation of protein export from nucleus|
|hydrogen peroxide metabolic process|
|peptidyl-cysteine modification|
|insulin secretion|
|repressing transcription factor binding|
|maintenance of protein localization in organelle|
|cytokine binding|
|negative regulation of intracellular protein transport|
|regulation of autophagy of mitochondrion|
|regulation of acute inflammatory response|
|negative regulation of response to endoplasmic reticulum stress|
|androgen receptor binding|
|regulation of lyase activity|
|response to copper ion|
|negative regulation of oxidative stress-induced cell death|
|positive regulation of ATP metabolic process|
|negative regulation of cellular response to oxidative stress|
|negative regulation of response to oxidative stress|
|negative regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of interleukin-8 production|
|positive regulation of reactive oxygen species biosynthetic process|
|regulation of ubiquitin-protein transferase activity|
|membrane depolarization|
|ammonium transport|
|regulation of transcription regulatory region DNA binding|
|positive regulation of oxidoreductase activity|
|negative regulation of reactive oxygen species metabolic process|
|regulation of monooxygenase activity|
|cellular aldehyde metabolic process|
|glutathione metabolic process|
|copper ion binding|
|positive regulation of DNA binding|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of proteasomal protein catabolic process|
|positive regulation of intrinsic apoptotic signaling pathway|
|peptide hormone secretion|
|scaffold protein binding|
|negative regulation of intracellular transport|
|regulation of cellular amino acid metabolic process|
|regulation of oxidative stress-induced cell death|
|regulation of interleukin-8 production|
|cellular response to hydrogen peroxide|
|regulation of mitochondrial membrane potential|
|regulation of protein acetylation|
|cellular ketone metabolic process|
|hormone secretion|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|cell body|
|negative regulation of protein ubiquitination|
|positive regulation of protein localization to nucleus|
|maintenance of protein location in cell|
|regulation of cellular response to oxidative stress|
|mitochondrial intermembrane space|
|primary alcohol metabolic process|
|adult locomotory behavior|
|regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of cellular amine metabolic process|
|hormone transport|
|peptidase activity|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of response to endoplasmic reticulum stress|
|regulation of response to oxidative stress|
|regulation of reactive oxygen species biosynthetic process|
|negative regulation of cellular protein catabolic process|
|negative regulation of cysteine-type endopeptidase activity|
|cellular oxidant detoxification|
|cellular response to ketone|
|kinase binding|
|positive regulation of protein binding|
|presynapse|
|positive regulation of reactive oxygen species metabolic process|
|regulation of oxidoreductase activity|
|negative regulation of intrinsic apoptotic signaling pathway|
|maintenance of location in cell|
|regulation of response to drug|
|PML body|
|cellular detoxification|
|negative regulation of extrinsic apoptotic signaling pathway|
|negative regulation of protein binding|
|double-stranded DNA binding|
|antibiotic metabolic process|
|cell-cell adherens junction|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of nucleocytoplasmic transport|
|maintenance of protein location|
|single-stranded DNA binding|
|positive regulation of transporter activity|
|alcohol biosynthetic process|
|reactive oxygen species metabolic process|
|negative regulation of cellular protein localization|
|chromatin|
|positive regulation of mitochondrion organization|
|regulation of protein localization to nucleus|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|positive regulation of autophagy|
|regulation of ATP metabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of DNA binding|
|detoxification|
|negative regulation of protein complex assembly|
|cellular response to reactive oxygen species|
|negative regulation of protein catabolic process|
|regulation of peptidyl-serine phosphorylation|
|organic hydroxy compound transport|
|positive regulation of small molecule metabolic process|
|positive regulation of inflammatory response|
|single fertilization|
|positive regulation of cation transmembrane transport|
|negative regulation of neuron apoptotic process|
|adult behavior|
|drug transport|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of ion transmembrane transport|
|protein secretion|
|regulation of generation of precursor metabolites and energy|
|establishment of protein localization to extracellular region|
|regulation of intrinsic apoptotic signaling pathway|
|mRNA binding|
|protein localization to nucleus|
|maintenance of location|
|positive regulation of protein kinase B signaling|
|protein localization to extracellular region|
|signal release|
|fertilization|
|negative regulation of binding|
|regulation of cellular ketone metabolic process|
|peptide secretion|
|positive regulation of apoptotic signaling pathway|
|positive regulation of binding|
|protein stabilization|
|neurotransmitter transport|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|negative regulation of protein transport|
|regulation of proteasomal protein catabolic process|
|glucose homeostasis|
|negative regulation of establishment of protein localization|
|organic hydroxy compound biosynthetic process|
|carbohydrate homeostasis|
|monocarboxylic acid biosynthetic process|
|response to ketone|
|locomotory behavior|
|response to reactive oxygen species|
|cellular modified amino acid metabolic process|
|regulation of protein ubiquitination|
|positive regulation of transmembrane transport|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|cellular response to toxic substance|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein binding|
|regulation of protein kinase B signaling|
|negative regulation of protein kinase activity|
|negative regulation of apoptotic signaling pathway|
|membrane raft|
|regulation of protein modification by small protein conjugation or removal|
|regulation of intracellular protein transport|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of kinase activity|
|Ras protein signal transduction|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|negative regulation of peptidase activity|
|process utilizing autophagic mechanism|
|positive regulation of DNA-binding transcription factor activity|
|autophagy|
|regulation of transmembrane transporter activity|
|protein-containing complex binding|
|positive regulation of ion transport|
|negative regulation of transferase activity|
|regulation of transporter activity|
|transcription coactivator activity|
|regulation of protein stability|
|axon|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|response to antibiotic|
|negative regulation of catabolic process|
|cadherin binding|
|regulation of neuron death|
|peptidyl-lysine modification|
|alcohol metabolic process|
|small GTPase mediated signal transduction|
|positive regulation of cellular protein localization|
|activation of protein kinase activity|
|regulation of autophagy|
|transcription factor binding|
|regulation of cation transmembrane transport|
|signaling receptor binding|
|regulation of inflammatory response|
|enzyme binding|
|regulation of supramolecular fiber organization|
|regulation of intracellular transport|
|regulation of neurotransmitter levels|
|negative regulation of proteolysis|
|positive regulation of cellular catabolic process|
|sulfur compound metabolic process|
|mitochondrial matrix|
|response to metal ion|
|regulation of binding|
|regulation of protein catabolic process|
|glycoprotein metabolic process|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|regulation of endopeptidase activity|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|regulation of DNA-binding transcription factor activity|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|positive regulation of catabolic process|
|trans-synaptic signaling|
|cofactor metabolic process|
|mitochondrion organization|
|regulation of peptidase activity|
|negative regulation of phosphorylation|
|nucleotide metabolic process|
|positive regulation of cytokine production|
|nucleoside phosphate metabolic process|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|organic hydroxy compound metabolic process|
|synaptic signaling|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|inflammatory response|
|drug metabolic process|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|DNA repair|
|peptide metabolic process|
|monocarboxylic acid metabolic process|
|response to inorganic substance|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|nucleobase-containing small molecule metabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|behavior|
|positive regulation of kinase activity|
|small molecule biosynthetic process|
|negative regulation of protein modification process|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|import into cell|
|regulation of cytokine production|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of cellular response to stress|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|regulation of defense response|
|cellular response to DNA damage stimulus|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|cation transport|
|sexual reproduction|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|oxidation-reduction process|
|regulation of transferase activity|
|positive regulation of transport|
|multi-organism reproductive process|
|negative regulation of cell death|
|regulation of catabolic process|
|oxoacid metabolic process|
|secretion by cell|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|regulation of organelle organization|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.36|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.14|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.04|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.9|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.83|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.81|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.77|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.76|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7601
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PARK7 Expression in NALM6 Cells: 6.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>