PARP10 [The Human Chemical-Genetic Interaction Map Project]

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======= PARP10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PARP10
  * **<color #00a2e8>Official Name</color>**: poly(ADP-ribose) polymerase family member 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84875|84875]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53GL7|Q53GL7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PARP10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PARP10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609564|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in cell proliferation. May be required for the maintenance of cell cycle progression. {ECO:0000269|PubMed:15674325, ECO:0000269|PubMed:16455663}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PARP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of chromatin assembly|
|negative regulation of protein K63-linked ubiquitination|
|negative regulation of protein polyubiquitination|
|regulation of chromatin assembly or disassembly|
|protein poly-ADP-ribosylation|
|regulation of protein K63-linked ubiquitination|
|protein auto-ADP-ribosylation|
|protein mono-ADP-ribosylation|
|NAD biosynthesis via nicotinamide riboside salvage pathway|
|protein ADP-ribosylase activity|
|K63-linked polyubiquitin modification-dependent protein binding|
|regulation of protein polyubiquitination|
|NAD+ ADP-ribosyltransferase activity|
|negative regulation of fibroblast proliferation|
|NAD biosynthetic process|
|protein ADP-ribosylation|
|pyridine nucleotide biosynthetic process|
|nicotinamide nucleotide biosynthetic process|
|pyridine nucleotide metabolic process|
|nicotinamide nucleotide metabolic process|
|pyridine-containing compound biosynthetic process|
|pyridine-containing compound metabolic process|
|translesion synthesis|
|oxidoreduction coenzyme metabolic process|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|negative regulation of viral genome replication|
|negative regulation of protein ubiquitination|
|negative regulation of viral life cycle|
|regulation of fibroblast proliferation|
|negative regulation of NF-kappaB transcription factor activity|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of viral genome replication|
|negative regulation of viral process|
|DNA biosynthetic process|
|coenzyme biosynthetic process|
|regulation of viral life cycle|
|negative regulation of DNA-binding transcription factor activity|
|regulation of chromatin organization|
|regulation of protein ubiquitination|
|regulation of viral process|
|cofactor biosynthetic process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of protein modification by small protein conjugation or removal|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|regulation of chromosome organization|
|regulation of DNA-binding transcription factor activity|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|DNA repair|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|negative regulation of protein modification process|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|nucleolus|
|organophosphate metabolic process|
|regulation of cellular component biogenesis|
|negative regulation of cellular protein metabolic process|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3029
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PARP10 Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>